ArticleScience translational medicine2015
Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension.
Article in Science translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- Cardiometabolic Multimorbidity and Sympathetic Overactivity: Translational Rationale for Combined Hepatic-Renal Denervation.JACC. Asia · 2026Review
- Cryoablation for Renal Denervation: A Cool Alternative to Thermal Approaches?JACC. Basic to translational science · 2025Article
- Cardiac Sympathetic Innervation and Ventricular Arrhythmias in Structural Heart Disease: Current Peripheral Neuromodulation Therapies and Emerging Therapeutic Targets.Arrhythmia & electrophysiology review · 2025Review
- High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation.Journal of cardiovascular translational research · 2024Article
- Management of patients with an electrical storm or clustered ventricular arrhythmias: a clinical consensus statement of the European Heart Rhythm Association of the ESC-endorsed by the Asia-Pacific Heart Rhythm Society, Heart Rhythm Society, and Latin-American Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Histological examination of renal nerve distribution, density, and function in humans.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- Translational value of preclinical models for renal denervation: a histological comparison of human versus porcine renal nerve anatomy.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- Morphometric analysis of the human common hepatic artery reveals a rich and accessible target for sympathetic liver denervation.Scientific reports · 2022Article
- The progress of pulmonary artery denervation.Cardiology journal · 2022Review
- An Open-label, Single-arm, Multicenter Feasibility Study Evaluating the Safety of Catheter-based Renal Denervation with DENEX™ in Patients with Uncontrolled Hypertension on Standard Medical Therapy.Korean circulation journal · 2021Article
- Is Renal Denervation Using Radiofrequency a Treatment Option for the Ventricular Arrhythmia Following Acute Myocardial Infarction?Korean circulation journal · 2020Article
- Effects of different ablation points of renal denervation on the efficacy of resistant hypertension.PeerJ · 2020Article
- The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies.Nature reviews. Cardiology · 2019Review
- Stereotactic Radiotherapy for Renal Denervation: To Beam, or Not to Beam?Journal of the American College of Cardiology · 2019Article
- Update on prevention and treatment of sudden cardiac arrest.Trends in cardiovascular medicine · 2019Review
- Joint UK societies' 2019 consensus statement on renal denervation.Heart (British Cardiac Society) · 2019Article
- Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience.Clinical and experimental nephrology · 2019Article
- Device-Based Neuromodulation for Resistant Hypertension Therapy.Circulation research · 2019Review
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12 authors at 1 institution in 1 country.
Funding
Abstract
Renal denervation (RDN) is a treatment option for patients with hypertension resistant to conventional therapy. Clinical trials have demonstrated variable benefit. To understand the determinants of successful clinical response to this treatment, we integrated porcine and computational models of intravascular radiofrequency RDN. Controlled single-electrode denervation resulted in ablation zone geometries that varied in arc, area, and depth, depending on the composition of the adjacent tissue substructure. Computational simulations predicted that delivered power density was influenced by tissue substructure, and peaked at the conductivity discontinuities between soft fatty adventitia and water-rich tissues (media, lymph nodes, etc.), not at the electrode-tissue interface. Electrode irrigation protected arterial wall tissue adjacent to the electrode by clearing heat that diffuses from within the tissue, without altering periarterial ablation. Seven days after multielectrode treatments, renal norepinephrine and blood pressure were reduced. Blood pressure reductions were correlated with the size-weighted number of degenerative nerves, implying that the effectiveness of the treatment in decreasing hypertension depends on the extent of nerve injury and ablation, which in turn are determined by the tissue microanatomy at the electrode site. These results may explain the variable patient response to RDN and suggest a path to more robust outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.