ArticleScience translational medicine2015
Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients.
Article in Science translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 157 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
157 citing papers in PubMed, 2 syntheses or guidelines pooled it, 481 citations in OpenAlex.
- Three-dimensional printing in medicine: a systematic review of pediatric applications.Pediatric research · 2021Pooled it
- The role of 3D printing in anatomy education and surgical training: A narrative review.MedEdPublish (2016) · 2017Pooled it
- Trial
- DLP-bioprinted ultrabiomimetic trachea with spatiotemporal angiogenesis regulation for segmental airway reconstruction.Science advances · 2026Article
- Clinical implementation of an EU MDR-compliant point-of-care manufacturing framework for patient-specific 3D-printed PEEK implants in craniomaxillofacial reconstruction.3D printing in medicine · 2026Article
- 4D Printing in Biomedical Implants and Functional Healthcare Devices.Journal of functional biomaterials · 2026Review
- Airway Malacia: Stent Innovations and Emerging Ex Vivo Testing Platforms.Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual · 2026Review
- 3-dimensional reconstruction and mixed reality in thoracic surgery: a narrative review and user guide.Journal of thoracic disease · 2025Review
- A Novel Approach for Tetralogy of Fallot-Absent Pulmonary Valve Using Bioresorbable Airway Splints.Pediatric cardiology · 2025Article
- The effects of recycling pharmaceutical formulations in laser powder bed fusion 3D printing - the influence of physical phenomena on printing performance.International journal of pharmaceutics: X · 2025Article
- Diagnosis, Treatment, and Follow-Up of Tracheo/Bronchomalacia in Children: The Italian Multicenter Experience.Children (Basel, Switzerland) · 2025Article
- Investigation of the biodegradation kinetics and associated mechanical properties of 3D-printed polycaprolactone during long-term preclinical testing.Biomaterials · 2025Article
- Method for Targeted Cellular Seeding of Tubular Tissue-Engineered Scaffolds for Tracheal Regeneration Approaches.ACS biomaterials science & engineering · 2025Article
- Review
- Transformative bioprinting: 4D printing and its role in the evolution of engineering and personalized medicine.Discover nano · 2025Review
- Novel Extraluminal silicone tracheal stent: Development and evaluation in a rabbit model of tracheomalacia.Animal models and experimental medicine · 2025Article
- Feasibility Assessment of 3D Printing-Based Tubular Tissue Flap in a Porcine Model for Long Segmental Tracheal Reconstruction.Tissue engineering and regenerative medicine · 2025Article
- Review
- Trends in 4D Printed Shape Memory Biomaterials for Tissue Engineering Applications.Current pharmaceutical design · 2025Review
- Degradation and Fatigue Behavior of 3D-Printed Bioresorbable Tracheal Splints.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
97 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Three-dimensional (3D) printing offers the potential for rapid customization of medical devices. The advent of 3D-printable biomaterials has created the potential for device control in the fourth dimension: 3D-printed objects that exhibit a designed shape change under tissue growth and resorption conditions over time. Tracheobronchomalacia (TBM) is a condition of excessive collapse of the airways during respiration that can lead to life-threatening cardiopulmonary arrests. We demonstrate the successful application of 3D printing technology to produce a personalized medical device for treatment of TBM, designed to accommodate airway growth while preventing external compression over a predetermined time period before bioresorption. We implanted patient-specific 3D-printed external airway splints in three infants with severe TBM. At the time of publication, these infants no longer exhibited life-threatening airway disease and had demonstrated resolution of both pulmonary and extrapulmonary complications of their TBM. Long-term data show continued growth of the primary airways. This process has broad application for medical manufacturing of patient-specific 3D-printed devices that adjust to tissue growth through designed mechanical and degradation behaviors over time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.