ArticleThe Journal of antimicrobial chemotherapy2015
Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis.
Article in The Journal of antimicrobial chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- A comparison of different antibiotic regimens for the treatment of infective endocarditis.The Cochrane database of systematic reviews · 2020Pooled it
- Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: Systematic review and meta-analysis-a report of the American Dental Association.Journal of the American Dental Association (1939) · 2019Pooled it
- Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association.Journal of the American Dental Association (1939) · 2019Guideline
- Antimicrobial agents for preventing urinary tract infections in adults undergoing cystoscopy.The Cochrane database of systematic reviews · 2019Pooled it
- Effectiveness of perioperative oral hygiene management using a cetylpyridinium chloride-, dipotassium glycyrrhizinate, and tranexamic acid-based mouthwash as an adjunct to mechanical oral hygiene in patients with maxillomandibular fixation: A randomized controlled clinical trial.Clinical and experimental dental research · 2023Trial
- Antibiotic Prophylaxis of Infective Endocarditis in Dentistry: An Update on the ESC, AHA, and NICE Guidelines.Journal of clinical medicine · 2026Review
- Antibiotics in Hand Surgery: Guidelines and Review.Journal of hand surgery global online · 2026Review
- Colonic epithelial regeneration shapes susceptibility tobioRxiv : the preprint server for biology · 2026Article
- 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Full version.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Article
- Infective Endocarditis Risk After Invasive Dental Procedures.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Antibiotic resistance: knowledge, attitudes, and prescribing behaviors among dental students: a cross-sectional study.Frontiers in oral health · 2025Article
- Adherence to the current guidelines on antibiotic prescription among dental practitioners: A national survey.PloS one · 2025Article
- Antibiotic prophylaxis in oral implant surgery in Germany: a cross-sectional study.International journal of implant dentistry · 2024Article
- Patterns of Antibiotic Prescription in Endodontic Therapy in the Republic of Croatia.Antibiotics (Basel, Switzerland) · 2024Article
- Barriers and facilitators to guideline concordant dental antibiotic prescribing in the United States: A qualitative study of the National Dental PBRN.Journal of public health dentistry · 2024Article
- Prevention of infective endocarditis in at-risk patients: how should dentists proceed in 2024?British dental journal · 2024Article
- New evidence calls into question NICE's endocarditis prevention guidance.British dental journal · 2024Article
- Endocarditis prevention: time for a review of NICE guidance.The Lancet regional health. Europe · 2024Review
- Facts and trends in dental antibiotic and analgesic prescriptions in Germany, 2012-2021.Clinical oral investigations · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesAntibiotic prophylaxis (AP) administration prior to invasive dental procedures has been a leading focus of infective endocarditis prevention. However, there have been long-standing concerns about the risk of adverse drug reactions as a result of this practice. The objective of this study was to identify the incidence and nature of adverse reactions to amoxicillin and clindamycin prophylaxis to prevent infective endocarditis.
methodsWe obtained AP prescribing data for England from January 2004 to March 2014 from the NHS Business Services Authority, and adverse drug reaction data from the Medicines and Healthcare Products Regulatory Agency's Yellow Card reporting scheme for prescriptions of the standard AP protocol of a single 3 g oral dose of amoxicillin or a single 600 mg oral dose of clindamycin for those allergic to penicillin.
resultsThe reported adverse drug reaction rate for amoxicillin AP was 0 fatal reactions/million prescriptions (in fact 0 fatal reactions for nearly 3 million prescriptions) and 22.62 non-fatal reactions/million prescriptions. For clindamycin, it was 13 fatal and 149 non-fatal reactions/million prescriptions. Most clindamycin adverse drug reactions were Clostridium difficile infections.
conclusionsAP adverse drug reaction reporting rates in England were low, particularly for amoxicillin, and lower than previous estimates. This suggests that amoxicillin AP is comparatively safe for patients without a history of amoxicillin allergy. The use of clindamycin AP was, however, associated with significant rates of fatal and non-fatal adverse drug reactions associated with C. difficile infections. These were higher than expected and similar to those for other doses, durations and routes of clindamycin administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.