ArticleCirculation research2015
Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions.
Open access · hybridAbstract read
In one paragraph
Article in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- The ILK-PINCH-parvin complex: a conserved primary adhesome regulating biological processes.Histochemistry and cell biology · 2025Review
- Mechanistic role of FN1 in LAIR-1 mediated downregulation of ovarian cancer cell proliferation.BMC cancer · 2025Article
- Endomucin regulates the endothelial cytoskeleton independently of VEGF.Experimental eye research · 2025Article
- Article
- Microvesicles derived from dermal myofibroblasts modify the integrity of the blood and lymphatic barriers using distinct endocytosis pathways.Journal of extracellular biology · 2024Article
- Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation.JCI insight · 2024Article
- Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy.Genes & diseases · 2023Article
- α-parvin controls chondrocyte column formation and regulates long bone development.Bone research · 2023Article
- Integrin-Dependent Cell-Matrix Adhesion in Endothelial Health and Disease.Circulation research · 2023Review
- CHILKBP protects against podocyte injury by preserving ZO-1 expression.Cellular and molecular life sciences : CMLS · 2022Article
- Actin cytoskeleton in angiogenesis.Biology open · 2022Review
- Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.Nature metabolism · 2021Article
- Review
- α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity.PloS one · 2020Article
- Coronin 1B Controls Endothelial Actin Dynamics at Cell-Cell Junctions and Is Required for Endothelial Network Assembly.Frontiers in cell and developmental biology · 2020Article
- Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.Nature communications · 2019Article
- PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production.Scientific reports · 2019Article
- A Novel Microscopic Assay Reveals Heterogeneous Regulation of Local Endothelial Barrier Function.Biophysical journal · 2019Article
- Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.The EMBO journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Alessia FraccaroliFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Bettina PitterFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Abdallah Abu TahaFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Jochen SeebachFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Stephan HuveneersFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Julian KirschFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Ricardo P Casaroli-MaranoFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Stefan ZahlerFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Ulrich PohlFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Holger GerhardtFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Hans-J SchnittlerFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.).
Eloi MontanezFrom the Walter-Brendel-Centre of Experimental Medicine (A.F., B.P., J.K., U.P., E.M.) and Department of Pharmacy (S.Z.), Ludwig-Maximilians University Munich, Munich, Germany; Institute of Anatomy and Vascular Biology, WWU-Münster, Münster, Germany (A.A.T., J.S., H.-J.S.); Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Swammerdam Institute for Life Sciences, Amsterdam, The Netherlands (S.H.); Department of Surgery, School of Medicine and Hospital Clinic de Barcelona (IDIBAPS), University of Barcelona, Barcelona, Spain (R.P.C.-M.); and Vascular Biology Laboratory, London Research Institute-Cancer Research United Kingdom, London, United Kingdom (H.G.). Eloi.Montanez@med.uni-muenchen.de.
Hospital Clínic de Barcelona · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversitat de Barcelona · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAngiogenesis and vessel integrity depend on the adhesion of endothelial cells (ECs) to the extracellular matrix and to adjacent ECs. The focal adhesion protein α-parvin (α-pv) is essential for vascular development. However, the role of α-pv in ECs in vivo is not known.
objectiveTo determine the function of α-pv in ECs during vascular development in vivo and the underlying mechanisms. METHODS AND
resultsWe deleted the α-pv gene specifically in ECs of mice to study its role in angiogenesis and vascular development. Here, we show that endothelial-specific deletion of α-pv in mice results in late embryonic lethality associated with hemorrhages and reduced vascular density. Postnatal-induced EC-specific deletion of α-pv leads to retinal hypovascularization because of reduced vessel sprouting and excessive vessel regression. In the absence of α-pv, blood vessels display impaired VE-cadherin junction morphology. In vitro, α-pv-deficient ECs show reduced stable adherens junctions, decreased monolayer formation, and impaired motility, associated with reduced formation of integrin-mediated cell-extracellular matrix adhesion structures and an altered actin cytoskeleton.
conclusionsEndothelial α-pv is essential for vessel sprouting and for vessel stability.
Indexed as
Adherens JunctionsAnimalsAntigens, CDBlood VesselsCadherin 5CadherinsCalponinsCell MovementCells, CulturedCell ShapeCytoskeletonEndothelial CellsEndothelium, VascularExtracellular MatrixFemaleGenes, LethalAntigens, CDCadherin 5CadherinsCalponinsMicrofilament ProteinsPARVA protein, humanParva protein, mouseRNA, Small Interferingadherens junctionsangiogenesisblood vesselscell adhesion moleculesgrowth and development
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.