Trial reportHormone research in paediatrics2015
Increased Prevalence of Sleep Apnea in Children with Pseudohypoparathyroidism Type 1a.
Trial report in Hormone research in paediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism
Effects of Theophylline on cAMP Signaling in Children With Pseudohypoparathyroidism Type 1a
Phase 2 Study of Theophylline Treatment for Pseudohypoparathyroidism
Phase 2 Study of Theophylline Treatment for Pseudohypoparathyroidism
Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Albright hereditary osteodystrophy: Delay in the diagnosis of a rare disorder due to restricted medical services.Clinical case reports · 2023Article
- Snow White and the Seven Dwarfs: a fairytale for endocrinologists.Endocrine connections · 2021Review
- Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders: An Updated Practical Tool for Physicians and Patients.Hormone research in paediatrics · 2020Review
- Management of pseudohypoparathyroidism.Current opinion in pediatrics · 2019Review
- Pseudohypoparathyroidism.Endocrinology and metabolism clinics of North America · 2018Review
- Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.Nature reviews. Endocrinology · 2018Review
- Obstructive Sleep Apnea and Otolaryngologic Manifestations in Children with Pseudohypoparathyroidism.Hormone research in paediatrics · 2018Article
- Nonclassic features of pseudohypoparathyroidism type 1A.Current opinion in endocrinology, diabetes, and obesity · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsPseudohypoparathyroidism type 1a (PHP1a) is a rare genetic disorder. This study aimed to determine the prevalence of sleep apnea in children with PHP1a.
methodsNineteen patients with PHP1a between the age of 2 and 21 years were enrolled prospectively using online advertisements. Parents completed a medical history and surveys to assess sleep behavior. Polysomnography records were obtained when available. In addition, 18 subjects were identified in a retrospective chart review of de-identified medical records with 2.3 million patient charts.
resultsParents reported sleep disturbance (94%) and daytime somnolence (81%) in their children with PHP1a. In the retrospective chart review, 39% had a history of sleep apnea versus 8.8% of a similarly obese control group. In the combined analysis (n = 31), 52% had a history of snoring and 45% had a diagnosis of sleep apnea. Patients were obese with a mean BMI z-score of 2.20 ± 0.59. Patients with sleep apnea were significantly younger than those without a diagnosis (8.1 ± 5.4 vs. 12.8 ± 5.0 years, p = 0.02).
conclusionsChildren with PHP1a have a 4.4-fold greater relative risk of sleep apnea than similarly obese children. Screening for sleep apnea in this population may be warranted to prevent adverse health outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.