ArticleSchizophrenia bulletin2015
New Targets for Prevention of Schizophrenia: Is It Time for Interventions in the Premorbid Phase?
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Global lifetime prevalence of schizophrenia: A systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Mentalizing Across the Psychosis Continuum in Adolescence and Young Adulthood: A Systematic Review and Narrative Synthesis.Schizophrenia bulletin · 2026Pooled it
- Continuum beliefs of mental illness: a systematic review of measures.Social psychiatry and psychiatric epidemiology · 2023Pooled it
- Advancements and Future Directions in Prevention Based on Evaluation for Individuals With Clinical High Risk of Psychosis: Insights From the SHARP Study.Schizophrenia bulletin · 2025Review
- Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder: A Danish Register-based Study.Schizophrenia bulletin · 2024Article
- Children at Familial High risk of Schizophrenia and Bipolar Disorder Exhibit Altered Connectivity Patterns During Pre-attentive Processing of an Auditory Prediction Error.Schizophrenia bulletin · 2024Article
- Exploring the relationship between frequent cannabis use, belief updating under uncertainty and psychotic-like symptoms.Frontiers in psychiatry · 2024Article
- The role of mentalizing in the relationship between schizotypal personality traits and state signs of psychosis risk captured by cognitive and perceptive basic symptoms.Frontiers in psychiatry · 2023Article
- Premorbid adjustment associates with cognitive and functional deficits in individuals at ultra-high risk of psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Effect of child abuse and neglect on schizophrenia and other psychotic disorders.Pharmacology, biochemistry, and behavior · 2021Review
- Preventive psychiatry: a blueprint for improving the mental health of young people.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Screening of the college students at clinical high risk for psychosis in China: a multicenter epidemiological study.BMC psychiatry · 2021Article
- Exploring Risk and Resilient Profiles for Functional Impairment and Baseline Predictors in a 2-Year Follow-Up First-Episode Psychosis Cohort Using Latent Class Growth Analysis.Journal of clinical medicine · 2020Article
- Psychomotor Slowing in Schizophrenia: Implications for Endophenotype and Biomarker Development.Biomarkers in neuropsychiatry · 2020Article
- Looking at Intergenerational Risk Factors in Schizophrenia Spectrum Disorders: New Frontiers for Early Vulnerability Identification?Frontiers in psychiatry · 2020Review
- Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study.Schizophrenia bulletin · 2019Article
- Article
- Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression: A Multimodal, Multisite Machine Learning Analysis.JAMA psychiatry · 2018Article
- Improving outcomes of first-episode psychosis: an overview.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- Mapping the Consequences of Impaired Synaptic Plasticity in Schizophrenia through Development: An Integrative Model for Diverse Clinical Features.Trends in cognitive sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A number of influences have converged that make this Special Theme Issue timely: "A New Direction: Considering Developmentally Sensitive Targets for Very Early Intervention in Schizophrenia". These factors include: 1. the substantial knowledge about premorbid developmental vulnerabilities to psychosis, especially regarding schizophrenia; 2. the promising results emerging from interventions during the clinical high-risk (CHR) phase of psychosis and; 3. the recognition that the CHR period is a relatively late phase of developmental derailment. These factors have together led to a perspective that even earlier intervention is warranted. This paper briefly summarizes the articles comprising the Special Theme including new data on early neurocognitive development, proposed potential targets for psychosocial and psychopharmacological interventions during the premorbid period as early as pregnancy, and ethical challenges. These thought experiments must be empirically tested, and the ethical challenges overcome as posed by the various interventions, which range from relatively low risk, supportive, psychosocial to higher risk, experimental, pharmacological interventions. All of the interventions proposed require careful study of ethics, safety, potential stigma, feasibility, efficacy and tolerability, and the meaning to the people involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.