ArticleCritical care (London, England)2015
Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management of NOACs in patients undergoing water vapour thermal therapy (REZUM) for benign prostatic obstruction: a comprehensive review.World journal of urology · 2025Pooled it
- Best practices in the management of proximal femoral fractures in elderly patients on the ward: a narrative review.EFORT open reviews · 2026Review
- Management of edoxaban therapy and clinical outcomes in patients undergoing major or nonmajor surgery: a subanalysis of the EMIT-AF/VTE study.Thrombosis journal · 2023Article
- Usefullness of Heparin Calibrated Anti-Xa Activity to Assess Anticoagulant Activity of Apixaban and Rivaroxaban in Emergency Patients Scheduled for Acute Interventions.Journal of clinical medicine · 2023Article
- A review of guidelines on anticoagulation reversal across different clinical scenarios - Is there a general consensus?The American journal of emergency medicine · 2020Review
- Review
- Perioperative management of anticoagulant therapy.Innovative surgical sciences · 2019Review
- [82 years old, male high-risk cardiac patient to planned Y-prosthesis implantation for abdominal aortic aneurysm : Preparation for the medical specialist examination: part 38].Der Anaesthesist · 2019Article
- Consensus Report on Patient Blood Management in Cardiac Surgery by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Cardiology (TSC), and Society of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care (SCTAIC).Turk gogus kalp damar cerrahisi dergisi · 2019Article
- Current status of oral anticoagulant reversal strategies: a review.Annals of translational medicine · 2019Review
- [Perioperative management of trauma surgery patients treated with direct oral anticoagulants].Der Unfallchirurg · 2019Article
- The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review.International journal of emergency medicine · 2018Review
- New oral anti-coagulation drugs and prostate biopsy: a call for guidelines.Therapeutic advances in urology · 2018Review
- Prothrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non-vitamin K Anticoagulant Reversal.Anesthesiology · 2018Review
- Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series.Journal of medical case reports · 2018Article
- [Perioperative handling of anticoagulation].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Review
- Use of Anticoagulants Remains a Significant Threat to Timely Hip Fracture Surgery.Geriatric orthopaedic surgery & rehabilitation · 2018Article
- Management of anticoagulation in hip fractures: A pragmatic approach.EFORT open reviews · 2017Article
- The role of new oral anticoagulants in orthopaedics: an update of recent evidence.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2017Review
- Perioperative management of patients on direct oral anticoagulants.Thrombosis journal · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perioperative management of patients treated with the non-vitamin K antagonist oral anticoagulants is an ongoing challenge. Due to the lack of good clinical studies involving adequate monitoring and reversal therapies, management requires knowledge and understanding of pharmacokinetics, renal function, drug interactions, and evaluation of the surgical bleeding risk. Consideration of the benefit of reversal of anticoagulation is important and, for some low risk bleeding procedures, it may be in the patient's interest to continue anticoagulation. In case of major intra-operative bleeding in patients likely to have therapeutic or supra-therapeutic levels of anticoagulation, specific reversal agents/antidotes would be of value but are currently lacking. As a consequence, a multimodal approach should be taken which includes the administration of 25 to 50 U/kg 4-factor prothrombin complex concentrates or 30 to 50 U/kg activated prothrombin complex concentrate (FEIBA®) in some life-threatening situations. Finally, further studies are needed to clarify the ideal therapeutic intervention.
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