ArticleJournal of assisted reproduction and genetics2015
Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Polycystic ovary syndrome (PCOS) affects relative embryo morphokinetics observed by time-lapse imaging: an observational study.Archives of gynecology and obstetrics · 2026Observational
- Differences in preimplantation blastocyst chromosomal aberrations between polycystic ovary syndrome women and controls: a multi-center retrospective cohort study.Journal of assisted reproduction and genetics · 2024Article
- Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?BMC pregnancy and childbirth · 2023Article
- Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.JBRA assisted reproduction · 2022Review
- Follicular fluid PlGF and IVF/ICSI outcomes among PCOS and normo-ovulatory women using different controlled hyperstimulation protocols: A prospective case-control study.Annals of medicine and surgery (2012) · 2022Article
- Long-term Hyperandrogenemia and/or Western-style Diet in Rhesus Macaque Females Impairs Preimplantation Embryogenesis.Endocrinology · 2022Article
- Review
- Higher preconceptional maternal body mass index is associated with faster early preimplantation embryonic development: the Rotterdam periconception cohort.Reproductive biology and endocrinology : RB&E · 2021Article
- Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls.F&S reports · 2020Article
- Intraindividual Embryo Morphokinetics Are Not Affected by a Switch of the Ovarian Stimulation Protocol Between GnRH Agonist vs. Antagonist Regimens in Consecutive Cycles.Frontiers in endocrinology · 2020Article
- Good practice recommendations for the use of time-lapse technologyHuman reproduction open · 2020Article
- Does polycystic ovary syndrome affect morphokinetics or abnormalities in early embryonic development?European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Revealing the secret life of pre-implantation embryos by time-lapse monitoring: A review.International journal of reproductive biomedicine · 2017Review
- Timing of human preimplantation embryonic development is confounded by embryo origin.Human reproduction (Oxford, England) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePolycystic ovarian syndrome (PCOS) is a common cause of female infertility. Factors other than anovulation, such as low embryo quality have been suggested to contribute to the infertility in these women. This 2-year retrospective study used timelapse technology to investigate the PCOS-influence on timing of development in the pre-implantation embryo (primary endpoint). The secondary outcome measure was live birth rates after elective single-embryo transfer.
methodsIn total, 313 embryos from 43 PCOS women, and 1075 embryos from 174 non-PCOS women undergoing assisted reproduction were included. All embryos were monitored until day 6. Differences in embryo kinetics were tested in a covariance regression model to account for potential confounding variables: female age, BMI, fertilization method and male infertility.
resultsTime to initiate compaction and reach the morula stage as well as the duration of the 4th cleavage division was significantly shorter in PCOS embryos compared with non-PCOS embryos. No other kinetic differences were found at any time-points annotated. The proportion of multi-nucleated cells at the 2-cell stage was significantly higher in PCOS embryos compared with non-PCOS embryos. The live birth rates were comparable between the two groups.
conclusionThe findings suggest that the causative factor for subfertility in PCOS is not related to timing of development in the pre-implantation embryo.
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