ReviewHeart failure reviews2015
Impact of pre-implant amiodarone exposure on outcomes in cardiac transplant recipients.
Review in Heart failure reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Post-transplant atrial tachyarrhythmias: Epidemiology, mechanisms, outcomes, and management across solid organs.World journal of transplantation · 2026Review
- Amiodarone use prior to cardiac transplant in children is associated with increased need for post-transplant chronotropic support.JHLT open · 2026Article
- Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone.Reviews in cardiovascular medicine · 2025Article
- Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival.Cardiovascular drugs and therapy · 2021Article
- Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post-transplant mortality.ESC heart failure · 2020Article
- Discontinuing amiodarone treatment prior to heart transplantation lowers incidence of severe primary graft dysfunction.Clinical transplantation · 2020Article
- Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017Article
- Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation.Drug design, development and therapy · 2017Article
- Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation.Drug design, development and therapy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amiodarone remains one of the preferred antiarrhythmic medications for patients with advanced heart failure awaiting cardiac transplant. However, the long half-life and rapid redistribution of this agent into donor myocardium expose heart transplant recipients to potential adverse outcomes. In reviewing the current body of literature, we found that pre-operative amiodarone exposure can increase the risk of bradycardia post-transplant; however, this is unlikely to require permanent pacemaker implant. Further, amiodarone has several serious drug-drug interactions with calcineurin inhibitors. Clinicians should therefore consider empiric reduction in initial dosing for tacrolimus or cyclosporine, and carefully monitor blood levels for at least 3 months post-transplant. Although the evidence is conflicting, amiodarone exposure pre-operatively may increase the risk of early graft failure and mortality. Amiodarone use should be minimized whenever possible; if amiodarone cannot practically be discontinued in the pre-transplant phase, judicious monitoring for QTc prolongation and ventricular arrhythmia should be implemented after transplant. As most of the studies included in this review suffered from small sample sizes and limited follow-up, additional research in this area is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.