Evidence map›Paper›PMID 25925212›Full record

ArticleAdvanced healthcare materials2015

A Processable Shape Memory Polymer System for Biomedical Applications.

Keith Hearon, Mark A Wierzbicki, Landon D Nash, Todd L Landsman, Christine Laramy, Alexander T Lonnecker, Michael C Gibbons, Sarah Ur, Kristen O Cardinal, Thomas S Wilson and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Keith Hearon5045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.
Mark A Wierzbicki5045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.
Landon D Nash5045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.
Todd L Landsman5045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.
Christine Laramy5045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.
Alexander T LonneckerDepartment of Chemistry, Texas A&M University, P.O. Box 30012, College Station, TX, 77842-3012, USA.
Michael C GibbonsBuilding 13, Room 263, Biomedical and General Engineering Department, California Polytechnic State University, San Luis Obispo, CA, 93407, USA.
Sarah UrBuilding 13, Room 263, Biomedical and General Engineering Department, California Polytechnic State University, San Luis Obispo, CA, 93407, USA.
Kristen O CardinalBuilding 13, Room 263, Biomedical and General Engineering Department, California Polytechnic State University, San Luis Obispo, CA, 93407, USA.
Thomas S Wilson7000 East Avenue, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA.
Karen L WooleyDepartment of Chemistry, Texas A&M University, P.O. Box 30012, College Station, TX, 77842-3012, USA.
Duncan J Maitland5045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.
Texas A&M University · USCalifornia Polytechnic State University · USLawrence Livermore National Laboratory · US

Funding

Shape Memory Polymer Devices for Treating StrokeR01EB000462 · NIBIB · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI MAITLAND, DUNCAN J · 2002 to 2012
$12.5M
NIBIB NIH HHS R01 EB000462NIBIB NIH HHS R01EB000462
6 · The paper itself

Abstract

Polyurethane shape memory polymers (SMPs) with tunable thermomechanical properties and advanced processing capabilities are synthesized, characterized, and implemented in the design of a microactuator medical device prototype. The ability to manipulate glass transition temperature (Tg ) and crosslink density in low-molecular weight aliphatic thermoplastic polyurethane SMPs is demonstrated using a synthetic approach that employs UV catalyzed thiol-ene "click" reactions to achieve postpolymerization crosslinking. Polyurethanes containing varying C=C functionalization are synthesized, solution blended with polythiol crosslinking agents and photoinitiator and subjected to UV irradiation, and the effects of number of synthetic parameters on crosslink density are reported. Thermomechanical properties are highly tunable, including glass transitions tailorable between 30 and 105 °C and rubbery moduli tailorable between 0.4 and 20 MPa. This new SMP system exhibits high toughness for many formulations, especially in the case of low crosslink density materials, for which toughness exceeds 90 MJ m(-3) at select straining temperatures. To demonstrate the advanced processing capability and synthetic versatility of this new SMP system, a laser-actuated SMP microgripper device for minimally invasive delivery of endovascular devices is fabricated, shown to exhibit an average gripping force of 1.43 ± 0.37 N and successfully deployed in an in vitro experimental setup under simulated physiological conditions.

Indexed as

Hot TemperaturePolyurethanesPolyurethanesbiomedical devicespolyurethaneshape memory polymersstructure-property relationshipsthiol-ene “click” chemistry

Identifiers

PMID25925212
PMCPMC4817840
OpenAlexW2089665419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.