Evidence map›Paper›PMID 25925184›Full record

ArticleThe Korean journal of parasitology2015

Genetic Polymorphisms in Plasmodium vivax Dihydrofolate Reductase and Dihydropteroate Synthase in Isolates from the Philippines, Bangladesh, and Nepal.

Pimwan Thongdee, Jiraporn Kuesap, Kanchana Rungsihirunrat, Shyam Prakash Dumre, Effie Espino, Harald Noedl, Kesara Na-Bangchang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Pimwan ThongdeeGraduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand ; Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand.
Jiraporn KuesapGraduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand.
Kanchana RungsihirunratMalaria Research Program, College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Shyam Prakash DumreWorld Health Organization-Nepal/Epidemiology and Disease Control Division (EDCD), DoHS, Teku Kathmandu, Nepal.
Effie EspinoResearch Institute for Tropical Medicine (RITM), Department of Health (DOH), Muntinlupa, Metro Manila, The Philippines.
Harald NoedlInstitute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
Kesara Na-BangchangGraduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand ; Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Pathumthani, Thailand.
Thammasat University · THChulalongkorn University · THDepartment of Health · PHMedical University of Vienna · AT

Funding

World Health Organization 001
6 · The paper itself

Abstract

Genetic polymorphisms of pvdhfr and pvdhps genes of Plasmodium vivax were investigated in 83 blood samples collected from patients in the Philippines, Bangladesh, and Nepal. The SNP-haplotypes of the pvdhfr gene at the amino acid positions 13, 33, 57, 58, 61, 117, and 173, and that of the pvdhps gene at the positions 383 and 553 were analyzed by nested PCR-RFLP. Results suggest diverse polymorphic patterns of pvdhfr alone as well as the combination patterns with pvdhps mutant alleles in P. vivax isolates collected from the 3 endemic countries in Asia. All samples carried mutant combination alleles of pvdhfr and pvdhps. The most prevalent combination alleles found in samples from the Philippines and Bangladesh were triple mutant pvdhfr combined with single mutant pvdhps allele and triple mutant pvdhfr combined with double wild-type pvdhps alleles, respectively. Those collected from Nepal were quadruple mutant pvdhfr combined with double wild-type pvdhps alleles. New alternative antifolate drugs which are effective against sulfadoxine-pyrimethamine (SP)-resistant P. vivax are required.

Indexed as

Polymorphism, GeneticAmino Acid SequenceBangladeshBase SequenceDihydropteroate SynthaseHumansMalaria, VivaxMolecular Sequence DataNepalPhilippinesPlasmodium vivaxTetrahydrofolate DehydrogenaseDihydropteroate SynthaseTetrahydrofolate DehydrogenasemalariaPCR-RFLPPlasmodium vivaxPlasmodium vivax dihydrofolate reductase (pvdhfr)Plasmodium vivax dihydropteroate synthase (pvdhps)sulfadoxine-pyrimethamine (SP)

Identifiers

PMID25925184
PMCPMC4416376
OpenAlexW2017475015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.