ArticleLipids in health and disease2015
Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents.
Article in Lipids in health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.Nature communications · 2024Article
- Saliva and Exhaled Breath Condensate Correlate With Serum in 4-12-Year-Olds Exposed to Secondhand Electronic Cigarette Vapors: A Pilot Study.Biological research for nursing · 2023Article
- Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes.International journal of hypertension · 2022Article
- Hepatic Fat in Early Childhood Is Independently Associated With Estimated Insulin Resistance: The Healthy Start Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Perspectives on youth-onset nonalcoholic fatty liver disease.Endocrinology, diabetes & metabolism · 2020Review
- Sex-Specific Metabolite Biomarkers of NAFLD in Youth: A Prospective Study in the EPOCH Cohort.The Journal of clinical endocrinology and metabolism · 2020Article
- Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease.Biomedicines · 2020Review
- Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism.Obesity (Silver Spring, Md.) · 2019Article
- Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics.Hepatology communications · 2019Article
- Nonalcoholic Fatty Liver Disease in Hispanic Youth With Dysglycemia: Risk for Subclinical Atherosclerosis?Journal of the Endocrine Society · 2017Article
- Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study.Children (Basel, Switzerland) · 2017Article
- Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children.Obesity facts · 2017Article
- Multifeature analysis of an ultrasound quantitative diagnostic index for classifying nonalcoholic fatty liver disease.Scientific reports · 2016Article
- Association of Non-alcoholic Fatty Liver Disease with Metabolic Syndrome Independently of Central Obesity and Insulin Resistance.Scientific reports · 2016Article
- Amino Acid Metabolism is Altered in Adolescents with Nonalcoholic Fatty Liver Disease-An Untargeted, High Resolution Metabolomics Study.The Journal of pediatrics · 2016Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNonalcoholic fatty liver disease (NAFLD) has emerged as the major pediatric chronic liver disease, and it is estimated to affect more than one third of obese children in the U.S. Cardiovascular complications are a leading cause of increased mortality in adults with NAFLD and many adolescents with NAFLD already manifest signs of subclinical atherosclerosis including increased carotid intima-media thickness.
methodsVolume of intrahepatic fat was assessed in 50 Hispanic-American, overweight adolescents, using Magnetic Resonance Spectroscopy. Lipoprotein compositions were measured using Nuclear Magnetic Resonance.
resultsPlasma triglycerides (TG) (p=0.003), TG/HDL ratio (p=0.006), TG/apoB ratio (p=0.011), large VLDL concentration (p=0.019), VLDL particle size (p=0.012), as well as small dense LDL concentration (p=0.026) progressively increased across higher levels of hepatic fat severity, while large HDL concentration progressively declined (p=0.043). This pattern of associations remained even after controlling for gender, BMI, visceral fat, and insulin resistance.
conclusionsOur findings suggest that increased hepatic fat is strongly associated with peripheral dyslipidemia and the amount of fat in the liver may influence cardiovascular risk. Further studies are needed to longitudinally monitor dyslipidemia in children with NAFLD and to examine whether the reduction of hepatic fat would attenuate their long-term CVD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.