ArticleAngewandte Chemie (International ed. in English)2015
Interfacing microbial styrene production with a biocompatible cyclopropanation reaction.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- Selective Iridium-Catalyzed Reductive Amination Inside Living Cells.Journal of the American Chemical Society · 2025Article
- A biocompatible Lossen rearrangement in Escherichia coli.Nature chemistry · 2025Article
- Concatenating Microbial, Enzymatic, and Organometallic Catalysis for Integrated Conversion of Renewable Carbon Sources.JACS Au · 2024Review
- Nucleophilic Carbenes Derived from Dichloromethane.Angewandte Chemie (International ed. in English) · 2023Article
- Article
- In Vivo Biocatalytic Cascades Featuring an Artificial-Enzyme-Catalysed New-to-Nature Reaction.Angewandte Chemie (International ed. in English) · 2023Article
- Palladium Nanoparticles fromJACS Au · 2022Article
- Tyramine Derivatives Catalyze the Aldol Dimerization of Butyraldehyde in the Presence of Escherichia coli.Chembiochem : a European journal of chemical biology · 2022Article
- Organometallic catalysis in aqueous and biological environments: harnessing the power of metal carbenes.Chemical science · 2022Review
- Article
- Micellar catalysis of the Suzuki Miyaura reaction using biogenic Pd nanoparticles fromGreen chemistry : an international journal and green chemistry resource : GC · 2021Article
- Exporting Metal-Carbene Chemistry to Live Mammalian Cells: Copper-Catalyzed Intracellular Synthesis of Quinoxalines Enabled by N-H Carbene Insertions.Angewandte Chemie (International ed. in English) · 2021Article
- Activation of C-O and C-N Bonds Using Non-Precious-Metal Catalysis.ACS catalysis · 2020Article
- Harnessing biocompatible chemistry for developing improved and novel microbial cell factories.Microbial biotechnology · 2020Review
- Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources.Nature communications · 2019Article
- A transition-metal-free & diazo-free styrene cyclopropanation.Chemical science · 2019Article
- Chemoenzymatic conversion of amides to enantioenriched alcohols in aqueous medium.Communications chemistry · 2019Article
- Carbene Transfer Reactions Catalysed by Dyes of the Metalloporphyrin Group.Molecules (Basel, Switzerland) · 2018Review
- Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions.Current opinion in biotechnology · 2017Review
- DNA-Accelerated Catalysis of Carbene-Transfer Reactions by a DNA/Cationic Iron Porphyrin Hybrid.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The introduction of new reactivity into living organisms is a major challenge in synthetic biology. Despite an increasing interest in both the development of small-molecule catalysts that are compatible with aqueous media and the engineering of enzymes to perform new chemistry in vitro, the integration of non-native reactivity into metabolic pathways for small-molecule production has been underexplored. Herein we report a biocompatible iron(III) phthalocyanine catalyst capable of efficient olefin cyclopropanation in the presence of a living microorganism. By interfacing this catalyst with E. coli engineered to produce styrene, we synthesized non-natural phenyl cyclopropanes directly from D-glucose in single-vessel fermentations. This process is the first example of the combination of nonbiological carbene-transfer reactivity with cellular metabolism for small-molecule production.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.