ArticleCritical care (London, England)2015
Functional outcome of prolonged refractory status epilepticus.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of topiramate as an add-on therapy in patients with refractory status epilepticus: a short systematic review.Revista Brasileira de terapia intensiva · 2021Pooled it
- Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open-label, dose-finding, phase 2 trial.Epilepsia · 2022Trial
- Prognostic Significance of Early Fever in Convulsive Status Epilepticus: Insights from the ICTAL Registry.Neurocritical care · 2026Article
- Management Challenges and Clinical Characteristics of Refractory Status Epilepticus in Mexico: A 102 Patient Retrospective Cohort Study.Neurocritical care · 2026Article
- Termination of super-refractory status epilepticus following stereo-EEG implantation.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Ketamine to Prevent Endotracheal Intubation in Adults with Refractory Non-convulsive Status Epilepticus: A Case Series.Neurocritical care · 2024Article
- Determinants of nutritional status and outcome in adults with RCSE: a retrospective cohort study.BMC neurology · 2021Article
- Electroconvulsive Therapy in Super Refractory Status Epilepticus: Case Series with a Defined Protocol.International journal of environmental research and public health · 2020Article
- Nonconvulsive seizures and nonconvulsive status epilepticus in the neuro ICU should or should not be treated aggressively: A debate.Clinical neurophysiology practice · 2019Review
- Long-term outcomes of status epilepticus: A critical assessment.Epilepsia · 2018Article
- Treatment of Refractory and Super-refractory Status Epilepticus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Acute Resective Surgery for the Treatment of Refractory Status Epilepticus.Neurocritical care · 2017Article
- Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case-Control Analysis from Germany.Frontiers in neurology · 2017Article
- A Study of Super Refractory Status Epilepticus from India.Frontiers in neurology · 2017Article
- Article
- Association of seizure duration and outcome in refractory status epilepticus.Journal of neurology · 2016Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo characterize etiology, clinical course and outcomes of patients in prolonged refractory status epilepticus (PRSE) and looking for prognostic factors.
methodsRetrospective study conducted in patients hospitalized from January 1, 2001 to December 31, 2011 in 19 polyvalent intensive care units in French university and general hospitals. Patients were adults with a generalized convulsive refractory status epilepticus that lasted more than seven days, despite treatment including an anesthetic drug and mechanical ventilation. Patients with anoxic encephalopathy were excluded. Follow-up phone call was used to determine functional outcome using modified Rankin Scale (mRS) with mRS 0-3 defining good and mRS 4-6 poor outcome.
results78 patients (35 female) were included. Median age was 57 years. Causes of status epilepticus were various, mainly including prior epilepsy (14.1%), CNS infection (12.8%), and stroke (12.8%). No etiology was found in 27 (34.6%) patients. PRSE was considered controlled in only 53 (67.9%) patients after a median duration of 17 (IQR 12-26) days. The median length of ICU stay was 28 (19-48) days. Forty-one (52.5%) patients died in the ICU, 26 from multiple organ failure, 8 from care withdrawal, 2 from sudden cardiac arrest, 1 from brain death and 4 from unknown causes. PRSE was previously resolved in 20 patients who died in the ICU. At one-year follow-up, there were 12 patients with good outcome and 58 with poor outcome and 8 lost of follow-up. On multivariate analysis, only vasopressor use was a predictor of poor outcome (OR 6.54; 95%CI 1.09-39.29; p = 0.04).
conclusionPoor outcome was observed in about 80% of this population of PRSE. Most patients died from systemic complications linked to their ICU stay. Some patients can recover satisfactorily over time though we did not identify any robust factor of good outcome.
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