Trial reportDiabetologia2015
Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study.
Trial report in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01559181 (Environmental Versus Genetic and Epigenetic Influences on Growth, Metabolism and Cognitive Function in Offspring of Mothers With Type 1 Diabetes), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Environmental Versus Genetic and Epigenetic Influences on Growth, Metabolism and Cognitive Function in Offspring of Mothers With Type 1 Diabetes
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Obesity and abnormal glucose tolerance in offspring of diabetic mothers: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring.Cell reports. Medicine · 2025Article
- The cardio-metabolic protein profile is associated with development of type 2 diabetes at long term follow-up after gestational diabetes mellitus: Results from the OGFUS study.Diabetes, obesity & metabolism · 2025Article
- Increased purchases of prescription medicines in offspring of women with type 1 diabetes: a Finnish register-based cohort study between 1995 and 2018.Annals of medicine · 2024Article
- Observational
- Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia.EMBO reports · 2024Article
- Blood pressure and lipid profiles in children born after ART with frozen embryo transfer.Human reproduction open · 2024Article
- Circulating Cytokine Levels and Cardiovascular Disease Risk Profile in Young Adult Offspring of Women with Type 1 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
- Maternal-fetal outcomes of pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion or multiple daily injections during pregnancy - A Brazilian health care referral center cohort study.Archives of endocrinology and metabolism · 2023Article
- Validation of Danish registry-cases of type 1 diabetes in women giving live birth using a clinical cohort as gold standard.Endocrinology, diabetes & metabolism · 2023Article
- Hyperglycemia in Pregnancy and Women's Health in the 21st Century.International journal of environmental research and public health · 2022Review
- Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study).BMC medicine · 2022Article
- Higher pulse wave velocity in young adult offspring of mothers with type 1 diabetes: a case-control study.Cardiovascular diabetology · 2022Article
- Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.Pediatric research · 2022Observational
- Article
- GAD65 autoantibodies and glucose tolerance in offspring born to women with and without type 1 diabetes (The EPICOM study).Endocrinology, diabetes & metabolism · 2022Article
- The long-term metabolic and neurocognitive risks in offspring of women with type 1 diabetes mellitus.Acta diabetologica · 2021Review
- Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring.International journal of environmental research and public health · 2021Article
- Skin Autofluorescence in Young Adult Offspring of Women with Type 1 Diabetes: A Cross-Sectional Case-Control Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Late-Pregnancy Fetal Hypoxia Is Associated With Altered Glucose Metabolism and Adiposity in Young Adult Offspring of Women With Type 1 Diabetes.Frontiers in endocrinology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWe aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers.
methodsDuring 1993-1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed.
resultsWe examined 278 index offspring (mean age 16.7 years; range 13.0-19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5-20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA1c levels in pregnancy were not directly associated with offspring metabolic outcomes. CONCLUSIONS/
interpretationAdolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA1c levels in pregnancy could not be demonstrated.
trial registrationClinicalTrials.gov NCT01559181.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.