Evidence map›Paper›PMID 25924930›Full record

ArticleClinical and experimental medicine2016

Increased B7H4 tissue expression correlates with high CA19.9 serum levels and a worse prognosis of pancreatic adenocarcinoma.

Anastasia Tsiaousidou, A K Tsaroucha, M Lambropoulou, M Pitiakoudis, A Polychronidis, E Chatzitheoklitos, K Romanidis, C Simopoulos

Abstract read
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In one paragraph

Article in Clinical and experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anastasia Tsiaousidou2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. natasha_tsia@yahoo.com.ORCID http://orcid.org/0000-0002-1083-766X
A K Tsaroucha2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
M LambropoulouLaboratory of Histology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
M Pitiakoudis2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
A Polychronidis1st Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
E ChatzitheoklitosDepartment of Surgery, General Hospital 'Agios Dimitrios', Thessaloniki, Greece.
K Romanidis2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
C Simopoulos2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Democritus University of Thrace · GRAgios Pavlos General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigated B7H4 protein expression in the PC tissue specimens of these patients by immunohistochemistry and analyzed several clinical and pathological features. The positive expression of the B7H4 antigen was associated with a negative impact of chemotherapy with gemcitabine on patient survival and also correlated with high CA19.9 serum levels and poorly differentiated tumors. Moreover, patients that overexpressed B7H4 antigen had worse prognosis compared to the ones that did not overexpress B7H4. B7H4 antigen is a negative prognostic marker for PC patients and also seems to express resistance of PC patients to chemotherapy with gemcitabine.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overAntigens, Tumor-Associated, CarbohydrateAntineoplastic AgentsBiomarkers, TumorDeoxycytidineFemaleGemcitabineHumansImmunohistochemistryMaleMiddle AgedPancreatic NeoplasmsPrognosisAntigens, Tumor-Associated, CarbohydrateAntineoplastic AgentsBiomarkers, TumorDeoxycytidineGemcitabineV-Set Domain-Containing T-Cell Activation Inhibitor 1B7H4BiomarkersChemotherapy resistanceImmunohistochemistryPancreatic cancer

Identifiers

PMID25924930
OpenAlexW2063470767

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.