ArticleRadiation oncology (London, England)2015
Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome in breast cancer patients is associated with age.
Article in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Incidence and prevalence of interstitial lung diseases worldwide: a systematic literature review.BMJ open respiratory research · 2023Pooled it
- Controversial issues in radiotherapy after breast-conserving surgery for early breast cancer in older patients: a systematic review.Journal of radiation research · 2018Pooled it
- Impact of COVID-19 vaccination on radiation-induced lung injury in breast cancer patients: a retrospective cohort study.Discover oncology · 2026Article
- Secondary Organizing Pneumonia: A Case Report of a Noteworthy Complication of Breast Irradiation.Cureus · 2025Article
- Oxytocin: A Shield against Radiation-Induced Lung Injury in Rats.Tomography (Ann Arbor, Mich.) · 2024Article
- Article
- Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe.Insights into imaging · 2021Review
- Effect of radiotherapy after breast-conserving surgery in elderly patients with early breast cancer according to the AJCC 8th Edition Breast Cancer Staging System in Japan.Breast cancer (Tokyo, Japan) · 2021Article
- Are there overlapping clinical features between thoracic radiotherapy side effects and covid-19 pneumonia? Radiation pneumonitis outside the radiation ports: Three case reports.Clinical and translational radiation oncology · 2020Article
- Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.Radiation oncology (London, England) · 2020Review
- Cryptogenic Organizing Pneumonia: Evolution of Morphological Patterns Assessed by HRCT.Diagnostics (Basel, Switzerland) · 2020Article
- Breast radiotherapy in elderly women: myths, controversies, and current techniques in the adjuvant setting.Translational cancer research · 2020Review
- Spontaneous resolution of thoracic radiation therapy-induced organizing pneumonia: A case series.Respiratory medicine case reports · 2019Article
- Incidence of organizing pneumonia after whole-breast radiotherapy for breast cancer, and risk factor analysis.Journal of radiation research · 2018Article
- Radiation-Induced Organizing Pneumonia: A Characteristic Disease that Requires Symptom-Oriented Management.International journal of molecular sciences · 2017Review
- Factors Associated With Radiation Pneumonitis in Patients Receiving Electron Boost Radiation for Breast-Conserving Therapy: A Retrospective Review.Advances in radiation oncologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a rarely observed phenomenon characterized by infiltration of the lungs outside of the radiation field, differentiating it from radiation pneumonitis (RP).The risk factors for radiation-induced BOOP (RT-BOOP) remain unclear and controversial. We retrospectively analyzed the incidence and risk factors for RT-BOOP associated with radiation therapy (RT) after breast conserving surgery (BCS) and post-mastectomy radiation therapy (PMRT). METHODS AND MATERIALS: We analyzed 1,176 breast cancer patients treated with RT after BCS or PMRT between March 2005 and September2008 at the cancer institute hospital of the Japanese foundation for cancer research. Chest radiographs were routinely obtained every three to six months for at least 12 months after surgery, as well as when the patients experienced respiratory symptoms or fever.
resultsRT-BOOP syndrome was diagnosed in 16patients (1.4%), including12BCS patients (1.3%) and four PMRT patients (1.8%). An older age (≥52 years old) was significantly associated with the incidence of RT-BOOP syndrome in a univariate analysis (p =0.023). The type of treatment (BCS or PMRT) and irradiated lung volume at 20 Gy (V20) were not significantly associated with the incidence of RT-BOOP syndrome in the entire patient cohort. In the multivariate analysis, age and smoking were the significant factor associated with RT-induced BOOP syndrome (p =0.044 and 0.049, respectively).
conclusionsRT-BOOP syndrome was a rarity, and the incidence for BCT cases was similar to that for PMRT cases. The irradiated lung volume was not significantly associated with RT-BOOP syndrome. An older age can predict the incidence of RT-BOOP syndrome.
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