Evidence map›Paper›PMID 25924761›Full record

ArticleClinical and vaccine immunology : CVI2015

Dysregulation of serum gamma interferon levels in vascular chronic Q Fever patients provides insights into disease pathogenesis.

Jeroen L A Pennings, Marjolein N T Kremers, Hennie M Hodemaekers, Julia C J P Hagenaars, Olivier H J Koning, Nicole H M Renders, Mirjam H A Hermans, Arja de Klerk, Daan W Notermans, Peter C Wever and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Recent Advances on the Innate Immune Response toFrontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jeroen L A PenningsCenter for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands jeroen.pennings@rivm.nl.ORCID http://orcid.org/0000-0002-9188-6358
Marjolein N T KremersDepartment of Internal Medicine, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Hennie M HodemaekersCenter for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Julia C J P HagenaarsDepartment of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Olivier H J KoningDepartment of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Nicole H M RendersDepartment of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Mirjam H A HermansDepartment of Molecular Diagnostics, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Arja de KlerkCenter for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Daan W NotermansCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Peter C WeverDepartment of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Riny JanssenCenter for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Jeroen Bosch Ziekenhuis · NLNational Institute for Public Health and the Environment · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large community outbreak of Q fever occurred in the Netherlands in the period 2007 to 2010. Some of the infected patients developed chronic Q fever, which typically includes pathogen dissemination to predisposed cardiovascular sites, with potentially fatal consequences. To identify the immune mechanisms responsible for ineffective clearance of Coxiella burnetii in patients who developed chronic Q fever, we compared serum concentrations of 47 inflammation-associated markers among patients with acute Q fever, vascular chronic Q fever, and past resolved Q fever. Serum levels of gamma interferon were strongly increased in acute but not in vascular chronic Q fever patients, compared to past resolved Q fever patients. Interleukin-18 levels showed a comparable increase in acute as well as vascular chronic Q fever patients. Additionally, vascular chronic Q fever patients had lower serum levels of gamma interferon-inducible protein 10 (IP-10) and transforming growth factor β (TGF-β) than did acute Q fever patients. Serum responses for these and other markers indicate that type I immune responses to C. burnetii are affected in chronic Q fever patients. This may be attributed to an affected immune system in cardiovascular patients, which enables local C. burnetii replication at affected cardiovascular sites.

Indexed as

AdultAgedAged, 80 and overChemokine CXCL10FemaleHumansInterferon-gammaMaleMiddle AgedNetherlandsQ FeverRetrospective StudiesSerumTransforming Growth Factor betaYoung AdultChemokine CXCL10CXCL10 protein, humanInterferon-gammaTransforming Growth Factor beta

Identifiers

PMID25924761
PMCPMC4446408
OpenAlexW2306655854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.