ArticleBMC psychiatry2015
Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case-control study.
Article in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Postoperative Risks in Thoracolumbar Fractures Patients with Mental Disorders: A Retrospective Cohort Study Using a Nationwide Inpatient Database.Spine surgery and related research · 2026Article
- Hyperhomocysteinemia is associated with the risk of venous thromboembolism in patients with mental illness: a case-control study.Frontiers in psychiatry · 2024Article
- Antipsychotic drugs as a contributing factor of pulmonary embolism: A report of 4 cases.Radiology case reports · 2023Article
- Current antipsychotic agent use and risk of venous thromboembolism and pulmonary embolism: a systematic review and meta-analysis of observational studies.Therapeutic advances in psychopharmacology · 2021Article
- Two pulmonary emboli in a psych pod.Journal of the American College of Emergency Physicians open · 2020Article
- Impact of drugs on venous thromboembolism risk in surgical patients.European journal of clinical pharmacology · 2019Review
- Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence.CNS drugs · 2018Review
- Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women.Journal of the American Heart Association · 2017Article
- Polypharmacotherapy and blood products as risk factors for venous thromboembolism in postsurgical patients: a case-control study.International journal of clinical pharmacy · 2017Article
- Antipsychotic drug exposure and risk of myocardial infarction.Epidemiology and psychiatric sciences · 2017Article
- Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review.Therapeutics and clinical risk management · 2017Review
- Big data for bipolar disorder.International journal of bipolar disorders · 2016Review
- Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder.Pulmonary circulationArticle
- Theoretical and practical issues related to the management of severe and refractory psychotic illness complicated by pulmonary embolism.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnly three observational studies investigated whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, with conflicting results. This study was therefore carried out to establish the risk of pulmonary embolism associated with antipsychotic drugs, and to ascertain the risk associated with first- and second-generation antipsychotic drugs, and with exposure to individual drugs.
methodsWe identified 84,253 adult individuals who began antipsychotic treatment in a large Italian health care system. Cases were all cohort members who were hospitalized for non-fatal or fatal pulmonary embolism during follow-up. Up to 20 controls for each case were extracted from the study cohort using incidence density sampling and matched by age at cohort entry and gender. Each individual was classified as current, recent or past antipsychotic user. The occurrence non-fatal or fatal pulmonary embolism was the outcome of interest.
resultsCompared to past use, current antipsychotic use more than double the risk of pulmonary embolism (odds ratio 2.31, 95% confidence interval 1.16 to 4.59), while recent use did not increase the risk. Both conventional and atypical antipsychotic exposure was associated with an increase in risk, and the concomitant use of both classes increased the risk of four times (odds ratio 4.21, 95% confidence interval 1.53 to 11.59).
conclusionsAdding the results of this case-control study to a recent meta-analysis of three observational studies substantially changed the overall estimate, which now indicates that antipsychotic exposure significantly increases the risk of pulmonary embolism.
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