ArticleOpen biology2015
Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.
Article in Open biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis.International journal of molecular medicine · 2026Article
- Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining.Arhiv za higijenu rada i toksikologiju · 2024Article
- The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation.Scientific reports · 2024Article
- Space radiation and the potential for early cataract development.Eye (London, England) · 2024Article
- Identification and quantification of ionising radiation-induced oxysterol formation in membranes of lens fibre cells.Advances in redox research · 2023Article
- Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens.The Journal of biological chemistry · 2022Review
- Radiation-Induced Alterations in Proliferation, Migration, and Adhesion in Lens Epithelial Cells and Implications for Cataract Development.Bioengineering (Basel, Switzerland) · 2022Article
- Effects of neutron radiation on Nrf2-regulated antioxidant defense systems in rat lens.Experimental and therapeutic medicine · 2021Article
- DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation.Scientific reports · 2020Article
- Long non-coding RNA nuclear paraspeckle assembly transcript 1 protects human lens epithelial cells against HAnnals of translational medicine · 2020Article
- An update on effects of ionizing radiation exposure on the eye.The British journal of radiology · 2020Review
- DNA damage in human skin and the capacities of natural compounds to modulate the bystander signalling.Open biology · 2019Review
- Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens.Scientific reports · 2019Article
- A biologically based mathematical model for spontaneous and ionizing radiation cataractogenesis.PloS one · 2019Article
- Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells.Radiation research · 2018Article
- Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.Radiation and environmental biophysics · 2018Article
- PARP-1/PAR Activity in Cultured Human Lens Epithelial Cells Exposed to Two Levels of UVB Light.Photochemistry and photobiology · 2018Article
- Article
- Fitness costs of increased cataract frequency and cumulative radiation dose in natural mammalian populations from Chernobyl.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing radiation (IR). Here, we show for the first time that in mice, lens epithelial cells (LECs) in the peripheral region repair DNA double strand breaks (DSB) after exposure to 20 and 100 mGy more slowly compared with circulating blood lymphocytes, as demonstrated by counts of γH2AX foci in cell nuclei. LECs in the central region repaired DSBs faster than either LECs in the lens periphery or lymphocytes. Although DSB markers (γH2AX, 53BP1 and RAD51) in both lens regions showed linear dose responses at the 1 h timepoint, nonlinear responses were observed in lenses for EdU (5-ethynyl-2'-deoxy-uridine) incorporation, cyclin D1 staining and cell density after 24 h at 100 and 250 mGy. After 10 months, the lens aspect ratio was also altered, an indicator of the consequences of the altered cell proliferation and cell density changes. A best-fit model demonstrated a dose-response peak at 500 mGy. These data identify specific nonlinear biological responses to low (less than 1000 mGy) dose IR-induced DNA damage in the lens epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.