ArticleBMC endocrine disorders2015
Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride.
Article in BMC endocrine disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of Exenatide and Humalog Mix25 on Fat Distribution, Insulin Sensitivity, andJournal of diabetes research · 2020Trial
- Sleep patterns, physical activity and glycemic control in newly diagnosed type 2 diabetes patients from a joint perspective: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study.BMC endocrine disorders · 2025Article
- Clinical characteristics and complication risks in data-driven clusters among Chinese community diabetes populations.Journal of diabetes · 2024Article
- A prospective guide for clinical implementation of selected OGTT- derived surrogate indices for the evaluation of β- cell function and insulin sensitivity in patients with transfusion-dependent β- thalassaemia.Acta bio-medica : Atenei Parmensis · 2023Article
- Association between tea consumption and glucose metabolism and insulin secretion in the Shanghai High-risk Diabetic Screen (SHiDS) study.BMJ open diabetes research & care · 2023Article
- Oral fat tolerance testing identifies abnormal pancreatic β-cell function and insulin resistance in individuals with normal glucose tolerance.Journal of diabetes investigation · 2022Article
- Article
- Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes.BMC endocrine disorders · 2021Article
- Effect of hypertriglyceridemia in dyslipidemia-induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study.Journal of diabetes investigation · 2021Article
- Prevalence of Insulin Receptor Substrate-1 Gene (G972R) Polymorphism, Insulin Resistance, and Determination of β-Cell Function among Overweight and Obese Persons with Type 2 Diabetes Mellitus.Journal of the ASEAN Federation of Endocrine Societies · 2021Article
- Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states.Lipids in health and disease · 2020Article
- An impaired glucagon-like peptide-1 response is associated with prediabetes in polycystic ovary syndrome with obesity.The Journal of international medical research · 2019Article
- Delay in glucose peak time during the oral glucose tolerance test as an indicator of insulin resistance and insulin secretion in type 2 diabetes patients.Journal of diabetes investigation · 2018Article
- A Study on the Factors Influencing Triglyceride Levels among Adults in Northeast China.Scientific reports · 2018Article
- Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach.Veterinary world · 2018Review
- Prediabetes and Cardiovascular Disease: Pathophysiology and Interventions for Prevention and Risk Reduction.Endocrinology and metabolism clinics of North America · 2018Review
- The Association Between an Addictive Tendency Toward Food and Metabolic Characteristics in the General Newfoundland Population.Frontiers in endocrinology · 2018Article
- Coffee consumption is positively related to insulin secretion in the Shanghai High-Risk Diabetic Screen (SHiDS) Study.Nutrition & metabolism · 2018Article
- Liraglutide ameliorates beta-cell function, alleviates oxidative stress and inhibits low grade inflammation in young patients with new-onset type 2 diabetes.Diabetology & metabolic syndrome · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore clinical characteristics and beta cell function in Chinese patients with newly diagnosed drug naive type 2 diabetes mellitus (T2DM) with different levels of serum triglyceride (TG).
methodsPatients with newly diagnosed T2DM (n = 624) were enrolled and divided into different groups according to levels of serum TG. All patients underwent oral glucose tolerance tests and insulin releasing tests. Demographic data, lipid profiles, glucose levels, and insulin profiles were compared between different groups. Basic insulin secretion function index (homeostasis model assessment for beta cell function index, HOMA-β), modified beta cell function index (MBCI), glucose disposition indices (DI), and early insulin secretion function index (insulinogenic index, IGI) were used to evaluate the beta cell function.
resultsPatients of newly diagnosed T2DM with hypertriglyceridemia were younger, fatter and had worse lipid profiles, glucose profiles, and high insulin levels than those with normal TG. There is no difference in early phase insulin secretion among groups of newly diagnosed T2DM patients with different TG levels. The basal beta cell function (HOMA-β and MBCI) initially increased along rising TG levels and then decreased as the TG levels rose further. The insulin sensitivity was relatively high in patients with a low level of TG and low with a high level of TG.
conclusionsHypertriglyceridemia influences clinical characteristics and β cell function of Chinese patients with newly diagnosed T2DM. A better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM.
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