Evidence map›Paper›PMID 25924234›Full record

ArticleOncotarget2015

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1.

Hyeongsun Moon, Jayde E Ruelcke, Eunju Choi, Laura J Sharpe, Zeyad D Nassar, Helle Bielefeldt-Ohmann, Marie-Odile Parat, Anup Shah, Mathias Francois, Kerry L Inder and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

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  19. Lipoprotein Drug Delivery Vehicles for Cancer: Rationale and Reason.International journal of molecular sciences · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Hyeongsun MoonThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Jayde E RuelckeThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Eunju ChoiThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Laura J SharpeSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia.
Zeyad D NassarThe School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia.
Helle Bielefeldt-OhmannSchool of Veterinary Science, The University of Queensland, Gatton, QLD, Australia.
Marie-Odile ParatThe School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia.
Anup ShahThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Mathias FrancoisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Kerry L InderThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Andrew J BrownSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia.
Pamela J RussellAustralian Prostate Cancer Research Centre-Queensland and Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Translational Research Institute, Brisbane, QLD, Australia.
Robert G PartonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Michelle M HillThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
University of Queensland · AUTranslational Research Institute · AUUNSW Sydney · AUCornell University · US

Funding

Worldwide Cancer Research 10-0517
6 · The paper itself

Abstract

Obesity and metabolic syndrome are associated with several cancers, however, the molecular mechanisms remain to be fully elucidated. Recent studies suggest that hypercholesterolemia increases intratumoral androgen signaling in prostate cancer, but it is unclear whether androgen-independent mechanisms also exist. Since hypercholesterolemia is associated with advanced, castrate-resistant prostate cancer, in this study, we aimed to determine whether and how hypercholesterolemia affects prostate cancer progression in the absence of androgen signaling. We demonstrate that diet-induced hypercholesterolemia promotes orthotopic xenograft PC-3 cell metastasis, concomitant with elevated expression of caveolin-1 and IQGAP1 in xenograft tumor tissues. In vitro cholesterol treatment of PC-3 cells stimulated migration and increased IQGAP1 and caveolin-1 protein level and localization to a detergent-resistant fraction. Down-regulation of caveolin-1 or IQGAP1 in PC-3 cells reduced migration and invasion in vitro, and hypercholesterolemia-induced metastasis in vivo. Double knock-down of caveolin-1 and IQGAP1 showed no additive effect, suggesting that caveolin-1 and IQGAP1 act via the same pathway. Taken together, our data show that hypercholesterolemia promotes prostate cancer metastasis independent of the androgen pathway, in part by increasing IQGAP1 and caveolin-1. These results have broader implications for managing metastasis of cancers in general as IQGAP1 and hypercholesterolemia are implicated in the progression of several cancers.

Indexed as

AnimalsCaveolin 1Cell Line, TumorDisease ProgressionHeterograftsHumansHypercholesterolemiaMaleMiceMice, Inbred NODMice, SCIDNeoplasm MetastasisProstatic Neoplasms, Castration-Resistantras GTPase-Activating ProteinsSignal TransductionCaveolin 1IQ motif containing GTPase activating protein 1ras GTPase-Activating Proteinscaveolin-1hypercholesterolemiaIQGAP1metastasisprostate cancer

Identifiers

PMID25924234
PMCPMC4480691
OpenAlexW1482544187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.