ArticleThe neuroradiology journal2015
Correlation of diffusion tensor imaging parameters in the canine brain.
Article in The neuroradiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Microstructural brain changes in Buerger's disease and smokers: a case-control study using diffusion tensor imaging.BMC medical imaging · 2026Article
- The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis.Scientific reports · 2025Article
- Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs.Frontiers in veterinary science · 2024Review
- Temporal and sequence-related variability in diffusion-weighted imaging of presumed cerebrovascular accidents in the dog brain.Frontiers in veterinary science · 2022Article
- Myelination of Callosal Axons Is Hampered by Early and Late Forelimb Amputation in Rats.Cerebral cortex communications · 2021Article
- Imaging Ischemic and Hemorrhagic Disease of the Brain in Dogs.Frontiers in veterinary science · 2020Review
- Tracking Inhibitory Control in Youth With ADHD: A Multi-Modal Neuroimaging Approach.Frontiers in psychiatry · 2020Article
- Maturation of Brain Microstructure and Metabolism Associates with Increased Capacity for Self-Regulation during the Transition from Childhood to Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine.CNS neuroscience & therapeutics · 2019Article
- Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury.Neural regeneration research · 2018Article
- Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.The neuroradiology journal · 2018Article
- Disruption of Accumbens and Thalamic White Matter Connectivity Revealed by Diffusion Tensor Tractography in Young Men with Genetic Risk for Obesity.Frontiers in human neuroscience · 2018Article
- Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.The neuroradiology journal · 2017Article
- Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.The neuroradiology journal · 2016Article
- Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging.The neuroradiology journal · 2016Article
- Predicting degree of myelination based on diffusion tensor imagining of canines with mucopolysaccharidosis type I.The neuroradiology journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The goal of this study was to determine the degree to which ex vivo diffusion tensor imaging (DTI) parameters correlate to one another in white matter regions on very high resolution MR scans. Specifically, we hypothesized that radial diffusivity (RD) and apparent diffusion coefficient (ADC) would correlate more closely than either would correlate with fractional anisotropy (FA). We performed post mortem DTI imaging on three canine brains on a 7 T MR scanner (TR = 100 ms, NEX = 1, gradient amplitude = 600 mT/m, b = 1492-1,565 s/mm²) and generated maps of FA, RD, and ADC. We measured RD, FA and ADC within 14 regions of interest representative of various portions of white matter. We compared the three combinations of values, i.e., FA vs ADC, FA vs RD and ADC vs RD, using linear regression models. Linear regression demonstrated that RD was significantly correlated with FA (p << 0.01; R² = 0.3053) and also with ADC (p << 0.01; R² = 0.6755), but to a much greater degree. However, ADC was not significantly correlated with FA (p = 0.526; R² = 0.101). Our findings suggest that both RD and ADC reflect similar cytoarchitectural features, most likely that of myelination, whereas FA values likely reflect both myelination and additional microstructural features that constrain the diffusion of water in white matter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.