ArticleKidney international2015
High cardiovascular event rates occur within the first weeks of starting hemodialysis.
Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparison of outcomes of incremental vs. standard peritoneal dialysis: a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- Incremental dialysis in ESRD: systematic review and meta-analysis.Journal of nephrology · 2019Pooled it
- Controversial issues in CKD clinical practice: position statement of the CKD-treatment working group of the Italian Society of Nephrology.Journal of nephrology · 2017Guideline
- Treatment of Anemia With Darbepoetin Prior to Dialysis Initiation and Clinical Outcomes: Analyses From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT).American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Trial
- Effectiveness of a New Single-Needle Single-Pump Dialysis System with Simultaneous Monitoring of Dialysis Dose.Artificial organs · 2018Trial
- Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients.Journal of the American Society of Nephrology : JASN · 2016Trial
- Ten tips for the first hemodialysis sessions.Clinical kidney journal · 2026Review
- Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study.Kidney research and clinical practice · 2026Article
- Applicability of the Framingham Risk Score in predicting mortality among kidney failure patients: an international analysis.Clinical kidney journal · 2025Article
- A time-dependent predictive model for cardiocerebral vascular events in chronic hemodialysis patients: insights from a prospective study.Frontiers in medicine · 2025Article
- Predicting early mortality in hemodialysis patients: a deep learning approach using a nationwide prospective cohort in South Korea.Scientific reports · 2024Article
- The Lack of a Standardized Definition of Chronic Dialysis Treatment in German Statutory Health Insurance Claims Data—Effects on Estimated Incidence and Mortality.Deutsches Arzteblatt international · 2024Observational
- Novel Perspectives in Chronic Kidney Disease-Specific Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Effect of sacubitril valsartan on heart failure with mid-range or preserved ejection fraction in patients on maintenance hemodialysis: real-world experience in a single-center, prospective study.BMC cardiovascular disorders · 2024Article
- Patient-focused outcomes after initiation of dialysis for ESRD: mortality, hospitalization and functional impairment.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Observational
- Time-Dependent Factors Influencing Cardiocerebral Vascular Events in Chronic Hemodialysis Patients: Insights from a Longitudinal Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Rates of adverse clinical events in patients with chronic kidney disease: analysis of electronic health records from the UK clinical practice research datalink linked to hospital data.BMC nephrology · 2023Article
- Health Services Use and Outcomes for Hospital Admissions With a Major Cardiovascular Event Recorded in Health Care Administrative Data in Patients Receiving Maintenance Hemodialysis: A Retrospective Cohort Study.Canadian journal of kidney health and disease · 2023Article
- Chinese Clinical Practice Guideline for the Management of "CKD-PeriDialysis"-the Periods Prior to and in the Early-Stage of Initial Dialysis.Kidney international reports · 2022Article
- [Heart and diabetes : Platelet function and antiplatelet therapy in chronic kidney disease].Herz · 2022Review
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early mortality is high in hemodialysis (HD) patients, but little is known about early cardiovascular event (CVE) rates after HD initiation. To study this we analyzed data in the AROii cohort of incident HD patients from over 300 European Fresenius Medical Care dialysis centers. Weekly rates of a composite of CVEs during the first year and monthly rates of the composite and its constituents (coronary artery, cerebrovascular, peripheral arterial, congestive heart failure, and sudden cardiac death) during the first 2 years after HD initiation were assessed. Of 6308 patients that started dialysis within 7 days, 1449 patients experienced 2405 CVEs over the next 2 years. The first-year CVE rate (30.2/100 person-years; 95% CI, 28.7-31.7) greatly exceeded the second-year rate (19.4/100; 95% CI, 18.1-20.8). Composite CVEs were highest during the first week with increased risk compared with the second year, persisting until the fifth month. Except for sudden cardiac death, temporal patterns of rates for all CVE categories were very similar, with highest rates during the first month and a high-risk period extending to 4 months. Higher or lower cumulative weekly dialysis dose, lower blood flow, and lower net ultrafiltration during dialysis were associated with CVE during the high-risk period, but not during the post high-risk period. Thus, the incidence of CVE in the first weeks after HD initiation is much higher than during subsequent periods which raises concerns that HD initiation may trigger CVEs.
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