ArticlePloS one2015
Specificity of Signal-Binding via Non-AHL LuxR-Type Receptors.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Bibliometric analysis and visualization of quorum sensing research over the last two decade.Frontiers in microbiology · 2024Pooled it
- You Talking to Me? Quorum Sensing in Symbiotic Microbes and Their Response to Environmental Variation.Microorganisms · 2026Review
- N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque.NPJ biofilms and microbiomes · 2025Article
- Assessment of the antibacterial and antioxidant activities of seaweed-derived extracts.Scientific reports · 2024Article
- Constructions of quorum sensing signaling network for activated sludge microbial community.ISME communications · 2024Article
- Review
- Resistance Is Not Futile: The Role of Quorum Sensing Plasticity inMicroorganisms · 2022Review
- Seaweeds in Pig Nutrition.Animals : an open access journal from MDPI · 2019Review
- An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation.PLoS pathogens · 2019Article
- Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host Interactomes.Frontiers in microbiology · 2019Article
- Article
- Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing.Frontiers in microbiology · 2017Article
- HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens.PloS one · 2017Article
- Specificity and complexity in bacterial quorum-sensing systems.FEMS microbiology reviews · 2016Review
- Antibacterial Derivatives of Marine Algae: An Overview of Pharmacological Mechanisms and Applications.Marine drugs · 2016Review
- Editorial: LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria.Frontiers in cellular and infection microbiology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing is a typical communication system among Gram-negative bacteria used to control group-coordinated behavior via small diffusible molecules dependent on cell number. The key components of a quorum sensing system are a LuxI-type synthase, producing acyl-homoserine lactones (AHLs) as signaling molecules, and a LuxR-type receptor that detects AHLs to control expression of specific target genes. Six conserved amino acids are present in the signal-binding domain of AHL-sensing LuxR-type proteins, which are important for ligand-binding and -specificity as well as shaping the ligand-binding pocket. However, many proteobacteria possess LuxR-type regulators without a cognate LuxI synthase, referred to as LuxR solos. The two LuxR solos PluR and PauR from Photorhabdus luminescens and Photorhabdus asymbiotica, respectively, do not sense AHLs. Instead PluR and PauR sense alpha-pyrones and dialkylresorcinols, respectively, and are part of cell-cell communication systems contributing to the overall virulence of these Photorhabdus species. However, PluR and PauR both harbor substitutions in the conserved amino acid motif compared to that in AHL sensors, which appeared to be important for binding the corresponding signaling molecules. Here we analyze the role of the conserved amino acids in the signal-binding domain of these two non-AHL LuxR-type receptors for their role in signal perception. Our studies reveal that the conserved amino acid motif alone is essential but not solely responsible for ligand-binding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.