Evidence map›Paper›PMID 25923685›Full record

ArticleThe neuroradiology journal2015

Unusual primary central nervous system lymphoma location involving the fourth ventricle and hypothalamus.

Michaela Cellina, Vincenza Fetoni, Pierluigi Baron, Marcello Orsi, Giancarlo Oliva

Abstract readCase Reports
In one paragraph

Article in The neuroradiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  15. Primary CNS Lymphoma Arising from the 4Case reports in oncological medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michaela CellinaRadiology Department, A.O. Fatebenefratelli e Oftalmico, Italy michaela.cellina@fbf.milano.it.
Vincenza FetoniRadiology Department, A.O. Fatebenefratelli e Oftalmico, Italy.
Pierluigi BaronRadiology Department, A.O. Fatebenefratelli e Oftalmico, Italy.
Marcello OrsiRadiology Department, A.O. Fatebenefratelli e Oftalmico, Italy.
Giancarlo OlivaRadiology Department, A.O. Fatebenefratelli e Oftalmico, Italy.
Azienda Ospedaliera Fatebenefratelli e Oftalmico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A previously healthy 65-year-old man presented with a two-week history of weight loss, headaches, blurred vision, asthenia and quickly worsening walking impairment. He denied photophobia, neck stiffness, fever, nausea or vomiting.Neurological examination showed global motor slowing, tendency to fall asleep during the clinical examination, generalized weakness against resistance to head and limbs, and osteotendon reflexes present in the upper limbs, but not evoked in the lower limbs. No sensitive deficit or focal neurologic sign was recognizable.Non-contrast multislice computed tomography (MSCT) of the head was performed in the emergency department, showing diffuse periventricular white matter and thalamic mild hyperdensity.Lumbar puncture, blood tests, including serology for HIV and other infections, were negative.On the third day the patient, showing decreased consciousness, underwent magnetic resonance imaging (MRI) with contrast medium injection. MRI revealed the presence of multiple pseudonodular avidly enhancing lesions, supra and infratentorial, crossing the midline, involving the ventricular system, including the fourth ventricle, with extension into the surrounding white matter, the corpus callosum, the thalamus and the hypothamalus.A stereotactic biopsy led to a diagnosis of diffuse large B-cell lymphoma, primarily located in the central nervous system (PCNSL).After the completion of the first phase of treatment (immunotherapy with intravenous Rituximab and corticosteroid), the MRI showed a marked regression of tumor masses.

Indexed as

Adrenal Cortex HormonesAgedAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsBrain NeoplasmsDiagnosis, DifferentialDrug Therapy, CombinationFemaleFourth VentricleHumansHypothalamusImmunologic FactorsLymphoma, B-CellMagnetic Resonance ImagingRituximabTomography, X-Ray ComputedAdrenal Cortex HormonesAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsImmunologic FactorsRituximabcentral nervous systemCT and MR imaginglymphomaneuroimagingprimary central nervous system lymphoma

Identifiers

PMID25923685
PMCPMC4757149
OpenAlexW2105623320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.