Trial reportThe neuroradiology journal2015
MRI DWI/ADC signal predicts shrinkage of lumbar disc herniation after O2-O3 discolysis.
Trial report in The neuroradiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 31 citations in OpenAlex.
- Efficacy of ultrasound guided caudal epidural steroid injection with or without ozone in patients with lumbosacral canal stenosis; a randomized clinical controlled trial.BMC musculoskeletal disorders · 2023Trial
- Indications and efficacy of O2-O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients.La Radiologia medica · 2016Trial
- Gas therapy: an innovative application for intervertebral disc degeneration.Medical gas research · 2026Review
- Medical Ozone as a Therapeutic Option in Musculoskeletal Pain Control: A Critical Review of Clinical Trials Considering Safety and Quality Indicators for Procedures and Devices.The Yale journal of biology and medicine · 2024Review
- New Approach to Chronic Back Pain Treatment: A Case Control Study.Biomedicines · 2022Article
- Advanced MRI imaging of nerve roots in lumbar radiculopathy due to discoradicular conflict: DWI, DTI, and T2 mapping with clinical and neurophysiological correlations.La Radiologia medica · 2022Article
- OInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients.International journal of environmental research and public health · 2022Observational
- Diagnostic and interventional radiology: an update.Acta bio-medica : Atenei Parmensis · 2020Article
- Predictive factors of volumetric reduction in lumbar disc herniation treated by O2-O3 chemiodiscolysis.Acta bio-medica : Atenei Parmensis · 2020Article
- Evaluation of intervertebral disc using T2 mapping sequences in patients undergoing ONeuroradiology · 2020Article
- High-resolution magnetic resonance imaging at 3T of pituitary gland: advantages and pitfalls.Gland surgery · 2019Review
- Radiation-induced brain cavernomas in elderly: review of the literature and a rare case report.Acta bio-medica : Atenei Parmensis · 2019Review
- Application of diffusion tensor imaging (DTI) and MR-tractography in the evaluation of peripheral nerve tumours: state of the art and review of the literature.Acta bio-medica : Atenei Parmensis · 2019Review
- Percutaneous ozone nucleolysis for lumbar disc herniation.Neuroradiology · 2018Article
- Comprehensive comparison of therapeutic efficacy of radiofrequency target disc decompression and nucleoplasty for lumbar disc herniation: a five year follow-up.International orthopaedics · 2018Article
- Dynamic MRI in the evaluation of the spine: state of the art.Acta bio-medica : Atenei Parmensis · 2018Review
- Developments in the management of bone metastases with interventional radiology.Acta bio-medica : Atenei Parmensis · 2018Review
- MRI findings in lumbar spine following OInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2017Article
- Imaging of post-operative spine in intervertebral disc pathology.Musculoskeletal surgery · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEvaluate the discal morpho-structural changes as a predictive sign in the clinical outcome after ozone therapy in lumbar disc herniation using the T2-shine through effect in diffusion-weighted imaging (DWI).
methodOne hundred and fifty-four patients suffering from lumbosciatica (89 men and 65 women; age range, 23-62 years) were included, previous MR study performed with FSE-T2 and T2-fat, SE-T1 and DWI sequences, and were randomly assigned to two groups. Seventy-seven patients (control group) underwent conservative treatment with intraforaminal injection of steroid and anaesthetic. The remaining 77 patients (study group) underwent the same treatment with the addition of oxygen-ozone (O2-O3). During the following six months, a MRI follow-up with the same sequences was performed. An intervertebral disc volumetric analysis (IDVA), DWI signal score and post treatment clinical outcome evaluation were performed for an assessment of hernia reduction. χ² test, Student's t test and analysis of covariance were used for comparison of variables.
resultsIn the study group, 58 of 77 patients had a successful outcome (responders). In the responders group, DWI T2-shine through effect was present during MRI follow-up and in particular in 53 of 77 patients in six months of follow-up (p < 0.05). Moreover, in the same group a statistically significant disc shrinkage was shown by IDVA in sixth months of follow-up (p < 0.05).
conclusionsT2-shine through effect in DWI is present before morphological disc reduction and moreover could be considered as a predictive sign of response to oxygen-ozone treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.