ArticleJournal of medicinal chemistry2015
Correlating molecular character of NIR imaging agents with tissue-specific uptake.
Article in Journal of medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Annulated cationic tetramethyl indo(di)carbocyanine dyes exhibit potent dark cytotoxicity in cancer cells.Dyes and pigments : an international journal · 2026Article
- Tumor-Embedded Nerve Surgery Using Dual-Channel Intraoperative Imaging Probes.ACS applied materials & interfaces · 2025Article
- Matrix-designed bright near-infrared fluorophores for precision peripheral nerve imaging.Biomaterials · 2025Article
- Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024Review
- Multivalent supramolecular fluorescent probes for accurate disease imaging.Science advances · 2024Article
- Thermal Truncation of Heptamethine Cyanine Dyes.Journal of the American Chemical Society · 2024Article
- Cy5 Dye Cassettes Exhibit Through-Bond Energy Transfer and Enable Ratiometric Fluorescence Sensing.The Journal of organic chemistry · 2024Article
- Synthesis, Optical Properties, and In Vivo Biodistribution Performance of Polymethine Cyanine Fluorophores.ACS pharmacology & translational science · 2023Article
- Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.View (Beijing, China) · 2022Article
- Synthesis of Substituted Cy5 Phosphoramidite Derivatives and Their Incorporation into Oligonucleotides Using Automated DNA Synthesis.ACS omega · 2022Article
- Effect of morpholine and charge distribution of cyanine dyes on cell internalization and cytotoxicity.Scientific reports · 2022Article
- Near-Infrared Heptamethine Cyanine Dyes for Nanoparticle-Based Photoacoustic Imaging and Photothermal Therapy.Journal of medicinal chemistry · 2021Article
- Potential of Cyanine Derived Dyes in Photodynamic Therapy.Pharmaceutics · 2021Review
- Donor acceptor fluorophores: synthesis, optical properties, TD-DFT and cytotoxicity studies.Organic & biomolecular chemistry · 2021Article
- Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.Scientific reports · 2021Article
- DNA Photocleavage in the Near-Infrared Wavelength Range by 2-Quinolinium Dicarbocyanine Dyes.Molecules (Basel, Switzerland) · 2020Article
- Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury.Frontiers in chemistry · 2020Article
- Near-Infrared Contrast Agents for Bone-Targeted Imaging.Tissue engineering and regenerative medicine · 2019Review
- Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity.Methods (San Diego, Calif.) · 2019Article
- Real-Time Fluorescence Imaging in Thoracic Surgery.The Korean journal of thoracic and cardiovascular surgery · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Near-infrared (NIR) fluorescent contrast agents are emerging in optical imaging as sensitive, cost-effective, and nonharmful alternatives to current agents that emit harmful ionizing radiation. Developing spectrally distinct NIR fluorophores to visualize sensitive vital tissues to selectively avoid them during surgical resection of diseased tissue is of great significance. Herein, we report the synthetic variation of pentamethine cyanine fluorophores with modifications of physicochemical properties toward prompting tissue-specific uptake into sensitive tissues (i.e., endocrine glands). Tissue-specific targeting and biodistribution studies revealed localization of contrast agents in the adrenal and pituitary glands, pancreas, and lymph nodes with dependence on molecular characteristics. Incorporation of hydrophobic heterocyclic rings, alkyl groups, and halogens allowed a fine-tuning capability to the hydrophobic character and dipole moment for observing perturbation in biological activity in response to minor structural alterations. These NIR contrast agents have potential for clinical translation for intraoperative imaging in the delineation of delicate glands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.