ArticlePloS one2015
Native Wolbachia from Aedes albopictus Blocks Chikungunya Virus Infection In Cellulo.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Host and geography shape microbial communities in Kenyan mosquitoes: insights from metatranscriptomics.mSystems · 2026Article
- The inhibition mechanism ofFrontiers in microbiology · 2026Review
- Improved RNA preparation for RNA-seq of the intracellular bacteriumFrontiers in microbiology · 2025Article
- Strain-specific quantification ofFrontiers in insect science · 2025Article
- UnveilingFrontiers in cellular and infection microbiology · 2025Article
- A change in circulating chikungunya virus variant impacts Aedes aegypti vector competence and spatiotemporal distribution of disease in Malaysia.PLoS neglected tropical diseases · 2024Article
- The interplay between vector microbial community and pathogen transmission on the invasive Asian tiger mosquito,Frontiers in microbiology · 2023Review
- Article
- Transient Introgression ofPathogens (Basel, Switzerland) · 2022Article
- Growth and Maintenance ofInsects · 2021Review
- Mayaro Virus: The Potential Role of Microbiota andPathogens (Basel, Switzerland) · 2021Article
- Blood Meals With Active and Heat-Inactivated Serum Modifies the Gene Expression and Microbiome ofFrontiers in microbiology · 2021Article
- Wolbachia strain wAlbB blocks replication of flaviviruses and alphaviruses in mosquito cell culture.Parasites & vectors · 2020Article
- Complete Genome Sequence of the Wolbachia wAlbB Endosymbiont of Aedes albopictus.Genome biology and evolution · 2019Article
- Conditions facilitating infection of mosquito cell lines with Wolbachia, an obligate intracellular bacterium.In vitro cellular & developmental biology. Animal · 2019Article
- Review
- Article
- Molecular evidence for new sympatric cryptic species of Aedes albopictus (Diptera: Culicidae) in China: A new threat from Aedes albopictus subgroup?Parasites & vectors · 2018Article
- Assessment of Aedes albopictus reference genes for quantitative PCR at different stages of development.PloS one · 2018Article
- Group B Wolbachia Strain-Dependent Inhibition of Arboviruses.DNA and cell biology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wolbachia, a widespread endosymbiont of terrestrial arthropods, can protect its host against viral and parasitic infections, a phenotype called "pathogen blocking". However, in some cases Wolbachia may have no effect or even enhance pathogen infection, depending on the host-Wolbachia-pathogen combination. The tiger mosquito Aedes albopictus is naturally infected by two strains of Wolbachia, wAlbA and wAlbB, and is a competent vector for different arboviruses such as dengue virus (DENV) and chikungunya virus (CHIKV). Interestingly, it was shown in some cases that Ae. albopictus native Wolbachia strains are able to inhibit DENV transmission by limiting viral replication in salivary glands, but no such impact was measured on CHIKV replication in vivo. To better understand the Wolbachia/CHIKV/Ae. albopictus interaction, we generated a cellular model using Ae. albopictus derived C6/36 cells that we infected with the wAlbB strain. Our results indicate that CHIKV infection is negatively impacted at both RNA replication and virus assembly/secretion steps in presence of wAlbB. Using FISH, we observed CHIKV and wAlbB in the same mosquito cells, indicating that the virus is still able to enter the cell in the presence of the bacterium. Further work is needed to decipher molecular pathways involved in Wolbachia-CHIKV interaction at the cellular level, but this cellular model can be a useful tool to study the mechanism behind virus blocking phenotype induced by Wolbachia. More broadly, this put into question the ecological role of Wolbachia symbiont in Ae. albopictus, but also the ability of the CHIKV to counteract Wolbachia's antiviral potential in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.