ReviewCurrent opinion in neurology2015
A tale of two approaches: how metagenomics and proteomics are shaping the future of encephalitis diagnostics.
Review in Current opinion in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Mass spectrometry-based proteomic techniques to identify cerebrospinal fluid biomarkers for diagnosing suspected central nervous system infections. A systematic review.The Journal of infection · 2019Pooled it
- Blockade of Interleukin-6 Receptor with Tocilizumab During the Acute Phase of Childhood Immune-Mediated Epilepsy can Lead to a Favorable Outcome - an Observational Study.Current neuropharmacology · 2026Observational
- Metatranscriptomic Identification of Trubanaman Virus Sequences in Patient with Encephalitis, Australia.Emerging infectious diseases · 2025Article
- Evaluation of multiple consensus criteria for autoimmune encephalitis and temporal analysis of symptoms in a pediatric encephalitis cohort.Frontiers in neurology · 2022Article
- Acute viral encephalitis associated with human parvovirus B19 infection: unexpectedly diagnosed by metagenomic next-generation sequencing.Journal of neurovirology · 2020Article
- Prospective Cohort Study of Next-Generation Sequencing as a Diagnostic Modality for Unexplained Encephalitis in Children.Journal of the Pediatric Infectious Diseases Society · 2020Article
- Predictors of Outcome in Clinically Diagnosed Viral Encephalitis Patients: A 5-Year Prospective Study.BioMed research international · 2020Article
- Autoimmune Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Clinicopathology conference: 41-year-old woman with chronic relapsing meningitis.Annals of neurology · 2019Article
- Diagnostic Testing of Neurologic Infections.Neurologic clinics · 2018Review
- Nonsuppurative (Aseptic) Meningoencephalomyelitis Associated with Neurovirulent Astrovirus Infections in Humans and Animals.Clinical microbiology reviews · 2018Review
- CNS Vasculitis: an Approach to Differential Diagnosis and Management.Current rheumatology reports · 2018Review
- A novel cause of chronic viral meningoencephalitis: Cache Valley virus.Annals of neurology · 2017Article
- Precision Metagenomics: Rapid Metagenomic Analyses for Infectious Disease Diagnostics and Public Health Surveillance.Journal of biomolecular techniques : JBT · 2017Article
- Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Clinical Approach to Encephalitis.Current neurology and neuroscience reports · 2016Review
- Chronic Meningitis: Simplifying a Diagnostic Challenge.Current neurology and neuroscience reports · 2016Article
- Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing.Genome medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewWe highlight how metagenomics and proteomics-based approaches are being applied to the problem of diagnosis in idiopathic encephalitis. RECENT
findingsLow cost, high-throughput next-generation sequencing platforms have enabled unbiased sequencing of biological samples. Rapid sequence-based computational algorithms then determine the source of all the nonhost (e.g., pathogen-derived) nucleic acids in a sample. This approach recently identified a case of neuroleptospirosis, resulting in a patient's dramatic clinical improvement with intravenous penicillin. Metagenomics also enabled the discovery of a neuroinvasive astrovirus in several patients. With regard to autoimmune encephalitis, advances in high throughput and efficient phage display of human peptides resulted in the discovery of autoantibodies against tripartite motif family members in a patient with paraneoplastic encephalitis. A complementary assay using ribosomes to display full-length human proteins identified additional autoantibody targets. SUMMARY: Metagenomics and proteomics represent promising avenues of research to improve upon the diagnostic yield of current assays for infectious and autoimmune encephalitis, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.