Evidence map›Paper›PMID 25922900›Full record

ArticleJournal of cellular and molecular medicine2015

Human umbilical cord mesenchymal stem cell transplantation restores damaged ovaries.

Shao-Fang Zhu, Hong-Bo Hu, Hong-Yan Xu, Xia-Fei Fu, Dong-Xian Peng, Wei-Yan Su, Yuan-Li He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shao-Fang ZhuMedical College of Shaoguan University, Shaoguan, GuangDong, China.
Hong-Bo HuDepartment of Obstetrics and Gynaecology, The Yuebei People's Hospital of Shaoguan, Shaoguan, GuangDong, China.
Hong-Yan XuDepartment of Obstetrics and Gynaecology, The Yuebei People's Hospital of Shaoguan, Shaoguan, GuangDong, China.
Xia-Fei FuDepartment of Obstetrics and Gynaecology, Zhujiang Hospital, Southern Medical University, Guangzhou, GuangDong, China.
Dong-Xian PengDepartment of Obstetrics and Gynaecology, Zhujiang Hospital, Southern Medical University, Guangzhou, GuangDong, China.
Wei-Yan SuMedical College of Shaoguan University, Shaoguan, GuangDong, China.
Yuan-Li HeDepartment of Obstetrics and Gynaecology, Zhujiang Hospital, Southern Medical University, Guangzhou, GuangDong, China.
Zhujiang Hospital · CNYue Bei People's Hospital · CNShaoguan University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian injury because of chemotherapy can decrease the levels of sexual hormones and potentia generandi of patients, thereby greatly reducing quality of life. The goal of this study was to investigate which transplantation method for human umbilical cord mesenchymal stem cells (HUMSCs) can recover ovarian function that has been damaged by chemotherapy. A rat model of ovarian injury was established using an intraperitoneal injection of cyclophosphamide. Membrane-labelled HUMSCs were subsequently injected directly into ovary tissue or tail vein. The distribution of fluorescently labelled HUMSCs, estrous cycle, sexual hormone levels, and potentia generandi of treated and control rats were then examined. HUMSCs injected into the ovary only distributed to the ovary and uterus, while HUMSCs injected via tail vein were detected in the ovary, uterus, kidney, liver and lung. The estrous cycle, levels of sex hormones and potentia generandi of the treated rats were also recovered to a certain degree. Moreover, in some transplanted rats, fertility was restored and their offspring developed normally. While ovary injection could recover ovarian function faster, both methods produced similar results in the later stages of observation. Therefore, our results suggest that transplantation of HUMSCs by tail vein injection represents a minimally invasive and effective treatment method for ovarian injury.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsApoptosisBody WeightCell CycleCell ProliferationCell ShapeFemaleHepatocyte Growth FactorHumansImmunophenotypingInsulin-Like Growth Factor IMesenchymal Stem CellsOvarian FollicleOvaryRats, WistarHepatocyte Growth FactorInsulin-Like Growth Factor IVascular Endothelial Growth Factor Ahuman umbilical cord mesenchymal stem cellovarian functionumbilical cord

Identifiers

PMID25922900
PMCPMC4568915
OpenAlexW1981885698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.