Evidence map›Paper›PMID 25922795›Full record

ArticlePeerJ2015

DCEMRI.jl: a fast, validated, open source toolkit for dynamic contrast enhanced MRI analysis.

David S Smith, Xia Li, Lori R Arlinghaus, Thomas E Yankeelov, E Brian Welch

Abstract read
In one paragraph

Article in PeerJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Medical physics challenges in clinical MR-guided radiotherapy.Radiation oncology (London, England) · 2020
    Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David S SmithInstitute of Imaging Science, Vanderbilt University , Nashville, TN , USA ; Department of Radiology and Radiological Sciences, Vanderbilt University , USA.
Xia LiInstitute of Imaging Science, Vanderbilt University , Nashville, TN , USA ; Department of Radiology and Radiological Sciences, Vanderbilt University , USA.
Lori R ArlinghausInstitute of Imaging Science, Vanderbilt University , Nashville, TN , USA ; Department of Radiology and Radiological Sciences, Vanderbilt University , USA.
Thomas E YankeelovInstitute of Imaging Science, Vanderbilt University , Nashville, TN , USA ; Department of Radiology and Radiological Sciences, Vanderbilt University , USA ; Department of Physics and Astronomy, Vanderbilt University , USA ; Department of Cancer Biology, Vanderbilt University , USA.
E Brian WelchInstitute of Imaging Science, Vanderbilt University , Nashville, TN , USA ; Department of Radiology and Radiological Sciences, Vanderbilt University , USA ; Department of Biomedical Engineering, Vanderbilt University , USA.

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Multidisciplinary Training in Basic and Translational Imaging of CancerR25CA092043 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2001 to 2015
$6.6M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
Evaluation of MRI Biomarkers of Breast Cancer ResponseR01CA129961 · NCI · VANDERBILT UNIVERSITY · PI YANKEELOV, THOMAS E · 2008 to 2011
$1.2M
Applying Compressed Sensing to Dynamic Contrast Enhanced MRI of Breast CancerK25CA176219 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SMITH, DAVID S · 2014 to 2019
$720k
NCI NIH HHS K25 CA176219NCI NIH HHS R01 CA129961NCI NIH HHS R25 CA092043NCI NIH HHS U01 CA142565NIBIB NIH HHS T32 EB001628
6 · The paper itself

Abstract

We present a fast, validated, open-source toolkit for processing dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data. We validate it against the Quantitative Imaging Biomarkers Alliance (QIBA) Standard and Extended Tofts-Kety phantoms and find near perfect recovery in the absence of noise, with an estimated 10-20× speedup in run time compared to existing tools. To explain the observed trends in the fitting errors, we present an argument about the conditioning of the Jacobian in the limit of small and large parameter values. We also demonstrate its use on an in vivo data set to measure performance on a realistic application. For a 192 × 192 breast image, we achieved run times of <1 s. Finally, we analyze run times scaling with problem size and find that the run time per voxel scales as O(N (1.9)), where N is the number of time points in the tissue concentration curve. DCEMRI.jl was much faster than any other analysis package tested and produced comparable accuracy, even in the presence of noise.

Indexed as

CancerDCEJuliaMagnetic resonance imagingMedical imagingNumerical methodsParallel computingqMRIQuantitative imaging biomarkers

Identifiers

PMID25922795
PMCPMC4411523

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.