Evidence map›Paper›PMID 25922709›Full record

ArticleJournal of thoracic disease2015

Efficacy and safety of endobronchial valves for advanced emphysema: a meta analysis.

Hua Liu, Meng Xu, Yiqun Xie, Jie Gao, Songshi Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hua Liu1 Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China ; 2 Department of Pulmonary Disease, Rugao Traditional Chinese Medicine Hospital, Rugao 226500, China.
Meng Xu1 Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China ; 2 Department of Pulmonary Disease, Rugao Traditional Chinese Medicine Hospital, Rugao 226500, China.
Yiqun Xie1 Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China ; 2 Department of Pulmonary Disease, Rugao Traditional Chinese Medicine Hospital, Rugao 226500, China.
Jie Gao1 Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China ; 2 Department of Pulmonary Disease, Rugao Traditional Chinese Medicine Hospital, Rugao 226500, China.
Songshi Ni1 Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China ; 2 Department of Pulmonary Disease, Rugao Traditional Chinese Medicine Hospital, Rugao 226500, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA meta-analysis was undertaken to evaluate the efficacy and safety of bronchoscopic lung volume reduction with endobronchial valves (EBV) for advanced emphysema.

methodsA systematic search was performed from PubMed, EMBASE, CNKI, Cochrane Library database. Randomized control clinical trials on treatment of emphysema for 3-12 months with the EBV compared with standard medications and sham EBV were reviewed. Inclusion criteria were applied to select patients with advanced emphysema treated with EBV. The primary outcome was the percentage of the forced expiratory volume in the first second (FEV1%). Secondary outcomes included St George's Respiratory Questionnaire (SGRQ) score, the distance of the 6-minute walk (6MWD) test, the Modified Medical Research Council (MMRC) dyspnoea score, cycle ergometry workload, and the rate of the six major complications at 3 or 12 months. Fixed- or random-effects models were used and weighted mean differences (WMD), relative risks (RR) and 95% confidence intervals (CI) were calculated.

resultsThree trials (565 patients) were considered in the meta-analysis. EBV patients yielded greater increases in FEV1% than standard medications (WMD =6.71; 95% CI, 3.31 to 10.10; P=0.0001), EBV patients also demonstrated a significant change for SGRQ score (WMD =-3.64; 95% CI, -5.93 to -1.34; P=0.002), MMRC dyspnoea score (WMD =-0.26; 95% CI, -0.44 to -0.08; P=0.004), and cycle ergometry workload (WMD =4.18; 95% CI, 2.14 to 6.22; P<0.0001). A similar level was evident for 6MWD (WMD =11.66; 95% CI, -3.31 to 26.64; P=0.13). EBV may increase the rate of hemoptysis (RR =5.15; 95% CI, 1.16 to 22.86; P=0.03), but didn't increase the adverse events including mortality, respiratory failure, empyema, pneumonia, pneumothrax. The overall rates for complications compared EBV with standard medications and sham EBV was not significant (RR =2.03; 95% CI, 0.98 to 4.21; P=0.06).

conclusionsEBV lung volume reduction for advanced emphysema showed superior efficacy and a good safety and tolerability compared with standard medications and sham EBV, further more randomized controlled trial (RCT) studies are needed to pay more attention to the long-term efficacy and safety of bronchoscopic lung volume reduction with EBV in advanced emphysema.

Indexed as

Bronchoscopeemphysemaendobronchial valves (EBV)

Identifiers

PMID25922709
PMCPMC4387449

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.