Evidence map›Paper›PMID 25922658›Full record

ArticleClinical sarcoma research2015

Do human tumor-associated viruses play a role in the development of synovial sarcoma?

Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger von Eisenhart-Rothe, Melanie Straub

Open access · diamondAbstract read
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In one paragraph

Article in Clinical sarcoma research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ulrich LenzeDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Florian PohligDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Heinrich MühlhoferDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Florian LenzeDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Andreas ToepferDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Hans RechlDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Rainer BurgkartDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Rüdiger von Eisenhart-RotheDepartment for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Melanie StraubInstitute of Pathology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Klinikum rechts der Isar · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas.

findingsIn total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected.

conclusionAn involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.

Indexed as

EBVHHV-8HPVSoft tissue sarcomaSynovial sarcomaVirus

Identifiers

PMID25922658
PMCPMC4412097
OpenAlexW2095339638

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.