ArticleEvidence-based complementary and alternative medicine : eCAM2015
Network pharmacology-based antioxidant effect study of zhi-zi-da-huang decoction for alcoholic liver disease.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Alcoholic Liver Disease in China: A Disease Influenced by Complex Social Factors That Should Not Be Neglected.Journal of clinical and translational hepatology · 2024Review
- Network Pharmacology Approach for Medicinal Plants: Review and Assessment.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Shenqi Yanshen Formula (SQYSF) protects against chronic kidney disease by modulating gut microbiota.Bioengineered · 2022Article
- System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of GanDouLing for Wilson's Disease.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective.Chinese journal of integrative medicine · 2020Review
- Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment.Frontiers in pharmacology · 2019Review
- Chinese herbal formula Fuzheng Huayu alleviates CClActa pharmacologica Sinica · 2018Article
- How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?Molecules (Basel, Switzerland) · 2017Review
- Systems Biology - A Pivotal Research Methodology for Understanding the Mechanisms of Traditional Medicine.Journal of pharmacopuncture · 2015Review
- Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian.TheScientificWorldJournal · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Zhi-Zi-Da-Huang decoction (ZZDHD), a classic traditional Chinese medicine (TCM) formula, has been used for centuries to treat alcoholic liver disease. Reliable therapeutics of ZZDHD has also been validated in clinical practice. In this study, molecular docking and network analysis were carried out to explore the antioxidative mechanism of ZZDHD as an effective therapeutic approach to treat alcoholic liver disease. Multiple active compounds of ZZDHD were screened based on four key original enzymes (cytochrome P450 2E1, xanthine oxidase, inducible nitric oxide synthase, and cyclooxygenase-2) involved in ethanol-induced oxidative stress damage. A drug-target network was constructed through network pharmacology analysis, which predicted the relationships of active ingredients to the targets. Some results had been verified by the previous experimental pharmacological studies; meanwhile, it was first reported that xanthine oxidase and eriocitrin, neoeriocitrin, isorhoifolin, and poncirin had interactions. The network pharmacology strategy used provided a forceful tool for searching the mechanism of action of TCM formula and novel bioactive ingredients.
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Registered trials
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