ReviewEnvironmental health insights2015
Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2 in Asthmatics.
Review in Environmental health insights, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Toxic exposure and kidney function: Urinary creatinine and glomerular filtration rate in traditional sulfur miners.Toxicology reports · 2026Article
- Analysing allergen-environment interactions to identify drivers of asthma presentations in Metropolitan Melbourne, 2017-2022.Scientific reports · 2026Article
- Toxic Effects of Sulfur Dioxide: A Review.Toxics · 2026Review
- Environmental lag effects and clinical characteristics of pediatric human parainfluenza virus type 3 infections.Scientific reports · 2025Article
- Achieving Sub-ppm Sensitivity in SOAngewandte Chemie (International ed. in English) · 2025Article
- Association of Short-Term Exposure to Air Pollution with Depression in Patients with Asthma: A Cross-Sectional Study in Delhi, India.Journal of health & pollution · 2024Article
- Environmental health risk assessment and acute effects of sulfur dioxide (SOToxicology reports · 2024Article
- Release of ATP in the lung evoked by inhalation of irritant gases in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Outdoor Air Pollution and Pediatric Respiratory Disease.Clinics in chest medicine · 2024Review
- Assessing the efficacy of aluminum metal clusters AlRSC advances · 2024Article
- Early life exposures of childhood asthma and allergies-an epidemiologic perspective.Frontiers in allergy · 2024Article
- Effects of Plant-Derived Polyphenols on the Antioxidant Activity and Aroma of Sulfur-Dioxide-Free Red Wine.Molecules (Basel, Switzerland) · 2023Article
- Spatial shifting of COVID-19 clusters and disease association with environmental parameters in India: A time series analysis.Environmental research · 2023Article
- Causal relationship between outdoor atmospheric quality and pediatric asthma visits in hangzhou.Heliyon · 2023Article
- Ambient Air Pollution and Kawasaki Disease in Korean Children: A Study of the National Health Insurance Claim Data.Journal of the American Heart Association · 2022Article
- Air pollution and hospitalization of patients with idiopathic pulmonary fibrosis in Beijing: a time-series study.Respiratory research · 2022Article
- Long-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice.Journal of inflammation research · 2022Article
- Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants.Journal of inflammation research · 2022Article
- Air pollution in Delhi, India: It's status and association with respiratory diseases.PloS one · 2022Article
- Early childhood traffic-related air pollution and risk of allergic rhinitis at 2-4 years of age modification by family stress and male gender: a case-control study in Shenyang, China.Environmental health and preventive medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sulfur dioxide (SO2) is a problematic inhalable air pollutant in areas of widespread industrialization, not only in the United States but also in countries undergoing rapid industrialization, such as China, and it can be a potential trigger factor for asthma exacerbations. It is known that asthmatics are sensitive to the effects of SO2; however, the basis of this enhanced sensitivity remains incompletely understood. A PubMed search was performed over the course of 2014, encompassing the following terms: asthma, airway inflammation, sulfur dioxide, IL-10, mouse studies, and human studies. This search indicated that biomarkers of SO2 exposure, SO2 effects on airway epithelial cell function, and animal model data are useful in our understanding of the body's response to SO2, as are SO2-associated amplification of allergic inflammation, and potential promotion of neurogenic inflammation due to chemical irritant properties. While definitive answers are still being sought, these areas comprise important foci of consideration regarding asthmatic responses to inhaled SO2. Furthermore, IL-10 deficiency associated with asthma may be another important factor associated with an inability to resolve inflammation and mitigate oxidative stress resulting from SO2 inhalation, supporting the idea that asthmatics are predisposed to SO2 sensitivity, leading to asthma exacerbations and airway dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.