ReviewMediators of inflammation2015
Inflammatory mediators in vascular disease: identifying promising targets for intracranial aneurysm research.
Review in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Is neutrophil-lymphocyte ratio a useful tool for predicting outcome in subarachnoid hemorrhage? A systematic review.Neurosurgical review · 2021Pooled it
- In the wall lies the truth: a systematic review of diagnostic markers in intracranial aneurysms.Brain pathology (Zurich, Switzerland) · 2020Pooled it
- Constructing a nomogram for short-term prognosis in postoperative patients with aneurysmal subarachnoid hemorrhage: a two-center retrospective study.Scientific reports · 2025Article
- Microcurrent wave alleviates mouse intracranial arterial dolichoectasia development.Scientific reports · 2024Article
- Cerebral Aneurysm and Interleukin-6: a Key Player in Aneurysm Generation and Rupture or Just One of the Multiple Factors?Translational stroke research · 2023Review
- Potential application of peripheral blood biomarkers in intracranial aneurysms.Frontiers in neurology · 2023Review
- High-Dimensional Immune Profiling by Mass Cytometry Revealed the Circulating Immune Cell Landscape in Patients With Intracranial Aneurysm.Frontiers in immunology · 2022Article
- Transcriptome-Based Dissection of Intracranial Aneurysms Unveils an "Immuno-Thermal" Microenvironment and Defines a Pathological Feature-Derived Gene Signature for Risk Estimation.Frontiers in immunology · 2022Article
- Pro-Inflammatory and Anti-Inflammatory Cytokines Levels are Significantly Altered in Cerebrospinal Fluid of Unruptured Intracranial Aneurysm (UIA) Patients.Journal of inflammation research · 2022Article
- Pharmacological inhibition of STAT3 by BP-1-102 inhibits intracranial aneurysm formation and rupture in mice through modulating inflammatory response.Pharmacology research & perspectives · 2021Article
- Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysms: A Histopathological Evaluation.Journal of the American Heart Association · 2021Article
- IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm.Journal of inflammation research · 2021Article
- Elevated Glucose-Potassium Ratio Predicts Preoperative Rebleeding in Patients With Aneurysmal Subarachnoid Hemorrhage.Frontiers in neurology · 2021Article
- Development and validation of a predictive model for the prognosis in aneurysmal subarachnoid hemorrhage.Journal of clinical laboratory analysis · 2020Article
- Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation.Bioscience reports · 2018Article
- Wall enhancement ratio and partial wall enhancement on MRI associated with the rupture of intracranial aneurysms.Journal of neurointerventional surgery · 2018Article
- Macrophage Polarization in Cerebral Aneurysm: Perspectives and Potential Targets.Journal of immunology research · 2017Review
- Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells.Journal of neuroinflammation · 2016Article
- Genetic association study identifies a functional CNV in the WWOX gene contributes to the risk of intracranial aneurysms.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory processes are implicated in many diseases of the vasculature and have been shown to play a key role in the formation of intracranial aneurysms (IAs). Although the specific mechanisms underlying these processes have been thoroughly investigated in related pathologies, such as atherosclerosis, there remains a paucity of information regarding the immunopathology of IA. Cells such as macrophages and lymphocytes and their effector molecules have been suggested to be players in IA, but their specific interactions and the role of other components of the inflammatory response have yet to be determined. Drawing parallels between the pathogenesis of IA and other vascular disorders could provide a roadmap for developing a mechanistic understanding of the immunopathology of IA and uncovering useful targets for therapeutic intervention. Future research should address the presence and function of leukocyte subsets, mechanisms of leukocyte recruitment and activation, and the role of damage-associated molecular patterns in IA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.