ArticleInternational journal of colorectal disease2015
Outcome for stage II and III rectal and colon cancer equally good after treatment improvement over three decades.
Article in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Ten-Year Outcomes of Patients with Rectal Cancer Remaining Lymph Node Positive After Preoperative Radiochemotherapy.Cancers · 2026Article
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- Sidedness is not a prognostic factor in an unselected cohort of patients with colon cancer but prognosis for caecal carcinoma is worse - A multivariate analysis of a large single institution database.International journal of colorectal disease · 2024Article
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- Perioperative and Oncological Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastasis of Rectal Origin.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Right colon, left colon, and rectal cancer have different oncologic and quality of life outcomes.International journal of colorectal disease · 2022Article
- Association of certification, improved quality and better oncological outcomes for rectal cancer in a specialized colorectal unit.International journal of colorectal disease · 2021Observational
- To what extent is the low anterior resection syndrome (LARS) associated with quality of life as measured using the EORTC C30 and CR38 quality of life questionnaires?International journal of colorectal disease · 2019Article
- An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients.International journal of cancer · 2018Article
- Outcome of bowel function following anterior resection for rectal cancer-an analysis using the low anterior resection syndrome (LARS) score.International journal of colorectal disease · 2018Article
- Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer.BMC medical research methodology · 2018Article
- Synchronous liver metastases in patients with rectal cancer: can we establish which treatment first?Therapeutic advances in medical oncology · 2018Article
- Preoperative Chemoradiotherapy Might Improve the Prognosis of Patients with Locally Advanced Low Rectal Cancer and Lateral Pelvic Lymph Node Metastases.World journal of surgery · 2017Article
- Article
- Proactive Management for Gastric, Colorectal and Appendiceal Malignancies: Preventing Peritoneal Metastases with Hyperthermic Intraperitoneal Chemotherapy (HIPEC).Indian journal of surgical oncology · 2016Review
- Tobramycin and bicarbonate synergise to kill planktonicNPJ biofilms and microbiomes · 2016Article
- Colorectal Cancer Survival Disparities among Puerto Rican Hispanics: A Comparison to Racial/Ethnic Groups in the United States.Cancer and clinical oncology · 2016Article
- Watch and wait approach to rectal cancer: A review.World journal of gastrointestinal surgery · 2015Review
Corrections and comments
- Erratum issuedErratum to: Outcome for stage II and III rectal and colon cancer equally good after treatment improvement over three decades.2016 · Joern, Fischer [corrected Fischer, Joern]; Gunter, Hellmich [Hellmich, Gunter]; Thomas, Jackisch [corrected to Jackisch, Thomas]; Erik, Puffer [corrected to Puffer, Erik]; Jörg, Zimmer [corrected to Zimmer, Jörg]; Dorothea, Bleyl [corrected to Bleyl, Dor
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the outcome for stage II and III rectal cancer patients compared to stage II and III colonic cancer patients with regard to 5-year cause-specific survival (CSS), overall survival, and local and combined recurrence rates over time.
methodsThis prospective cohort study identified 3,355 consecutive patients with adenocarcinoma of the colon or rectum and treated in our colorectal unit between 1981 and 2011, for investigation. The study was restricted to International Union Against Cancer (UICC) stages II and III. Postoperative mortality and histological incomplete resection were excluded, which left 995 patients with colonic cancer and 726 patients with rectal cancer for further analysis.
resultsFive-year CSS rates improved for colonic cancer from 65.0% for patients treated between 1981 and 1986 to 88.1% for patients treated between 2007 and 2011. For rectal cancer patients, the respective 5-year CSS rates improved from 53.4% in the first observation period to 89.8% in the second one. The local recurrence rate for rectal cancer dropped from 34.2% in the years 1981-1986 to 2.1% in the years 2007-2011. In the last decade of observation, prognosis for rectal cancer was equal to that for colon cancer (CSS 88.6 vs. 86.7%, p = 0.409).
conclusionSurvival of patients with colon and rectal cancer has continued to improve over the last three decades. After major changes in treatment strategy including introduction of total mesorectal excision and neoadjuvant (radio)chemotherapy, prognosis for stage II and III rectal cancer is at least as good as for stage II and III colonic cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.