ArticlePlant physiology2015
Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis Glycosyltransferases.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 148 citations in OpenAlex.
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- Transcriptomic Insights into the Enhanced Aroma of Guangdong Oolong Dry Tea (Foods (Basel, Switzerland) · 2024Article
- The sugar donor specificity of plant family 1 glycosyltransferases.Frontiers in bioengineering and biotechnology · 2024Review
- Exploring the Evolvability of Plant Specialized Metabolism: Uniqueness Out Of Uniformity and Uniqueness Behind Uniformity.Plant & cell physiology · 2023Review
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- The apiosyltransferase celery UGT94AX1 catalyzes the biosynthesis of the flavone glycoside apiin.Plant physiology · 2023Article
- Application of Multi-Perspectives in Tea Breeding and the Main Directions.International journal of molecular sciences · 2023Review
- Alternative Identification of Glycosides Using MS/MS Matching with an In Silico-Modified Aglycone Mass Spectra Library.Analytical chemistry · 2023Article
- Molecular Identification of UDP-Sugar-Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L.Plant & cell physiology · 2023Article
- Multiomics analysis of the mechanisms behind flavonoid differences between purple and green tender shoots of Camellia sinensis var. assamica.G3 (Bethesda, Md.) · 2023Article
- Genome-wide identification of UDP-glycosyltransferases in the tea plant (Frontiers in plant science · 2023Review
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Authors and funding
13 authors at 4 institutions in 1 country.
Shoji OhgamiGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Eiichiro OnoGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.) eiichiro_ono@suntory.co.jp dtonish@ipc.shizuoka.ac.jp.
Manabu HorikawaGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Jun MurataGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Koujirou TotsukaGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Hiromi ToyonagaGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Yukie OhbaGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Hideo DohraGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Tatsuo AsaiGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Kenji MatsuiGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).ORCID http://orcid.org/0000-0002-4875-5176
Masaharu MizutaniGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Naoharu WatanabeGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.).
Toshiyuki OhnishiGraduate School of Agriculture (S.O., K.T., Y.O., T.A., T.O.) and Research Institute of Green Science and Technology (H.D., T.O.), Shizuoka University, Shizuoka 422-8529, Japan;Research Institute, Suntory Global Innovation Center, Shimamoto, Mishima, Osaka 618-8503, Japan (E.O., H.T.);Bioorganic Research Institute, Suntory Foundation for Life Sciences, Shimamoto, Mishima, Osaka 618-8503, Japan (M.H., J.M.);Graduate School of Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan (K.M.);Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan (M.M.); andGraduate School of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan (N.W.) eiichiro_ono@suntory.co.jp dtonish@ipc.shizuoka.ac.jp.ORCID http://orcid.org/0000-0001-6862-9639
Suntory Foundation for Life Sciences · JPShizuoka University · JPSuntory (Japan) · JPYamaguchi University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tea plants (Camellia sinensis) store volatile organic compounds (VOCs; monoterpene, aromatic, and aliphatic alcohols) in the leaves in the form of water-soluble diglycosides, primarily as β-primeverosides (6-O-β-D-xylopyranosyl-β-D-glucopyranosides). These VOCs play a critical role in plant defenses and tea aroma quality, yet little is known about their biosynthesis and physiological roles in planta. Here, we identified two UDP-glycosyltransferases (UGTs) from C. sinensis, UGT85K11 (CsGT1) and UGT94P1 (CsGT2), converting VOCs into β-primeverosides by sequential glucosylation and xylosylation, respectively. CsGT1 exhibits a broad substrate specificity toward monoterpene, aromatic, and aliphatic alcohols to produce the respective glucosides. On the other hand, CsGT2 specifically catalyzes the xylosylation of the 6'-hydroxy group of the sugar moiety of geranyl β-D-glucopyranoside, producing geranyl β-primeveroside. Homology modeling, followed by site-directed mutagenesis of CsGT2, identified a unique isoleucine-141 residue playing a crucial role in sugar donor specificity toward UDP-xylose. The transcripts of both CsGTs were mainly expressed in young leaves, along with β-primeverosidase encoding a diglycoside-specific glycosidase. In conclusion, our findings reveal the mechanism of aroma β-primeveroside biosynthesis in C. sinensis. This information can be used to preserve tea aroma better during the manufacturing process and to investigate the mechanism of plant chemical defenses.
Indexed as
BiocatalysisCamellia sinensisGene Expression Regulation, EnzymologicGlycosidesGlycosylationGlycosyltransferasesKineticsMolecular Sequence DataMutagenesisOrgan SpecificityPhylogenyPlant LeavesRNA, MessengerStructural Homology, ProteinSubstrate SpecificityVolatile Organic CompoundsGlycosidesGlycosyltransferasesRNA, MessengerVolatile Organic Compounds
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