ArticleCell reports2015
Cis regulatory effects on A-to-I RNA editing in related Drosophila species.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing.Advanced biotechnology · 2026Article
- Biochemical profiling and structural basis of ADAR1-mediated RNA editing.Molecular cell · 2025Article
- Harnessing ADAR-Mediated Site-Specific RNA Editing in Immune-Related Disease: Prediction and Therapeutic Implications.International journal of molecular sciences · 2023Review
- An evolutionarily conserved mechanism that amplifies the effect of deleterious mutations in osteosarcoma.Molecular genetics and genomics : MGG · 2022Article
- Context-dependent and -independent selection on synonymous mutations revealed by 1,135 genomes of Arabidopsis thaliana.BMC ecology and evolution · 2021Article
- Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis.Nature communications · 2021Article
- What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs.Open biology · 2020Review
- Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.Cell reports · 2020Article
- The landscape of the A-to-I RNA editome from 462 human genomes.Scientific reports · 2018Article
- A-to-I RNA editing - immune protector and transcriptome diversifier.Nature reviews. Genetics · 2018Review
- An Evolutionary Landscape of A-to-I RNA Editome across Metazoan Species.Genome biology and evolution · 2018Article
- Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates.Nature communications · 2017Article
- Structure-mediated modulation of mRNA abundance by A-to-I editing.Nature communications · 2017Article
- The evolution and adaptation of A-to-I RNA editing.PLoS genetics · 2017Review
- Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs.Genome biology · 2017Review
- Article
- Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing.PLoS genetics · 2017Article
- Article
- Genetic Determinants of RNA Editing Levels of ADAR Targets in Drosophila melanogaster.G3 (Bethesda, Md.) · 2015Article
- The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3.G3 (Bethesda, Md.) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine-to-inosine RNA editing modifies maturing mRNAs through the binding of adenosine deaminase acting on RNA (Adar) proteins to double-stranded RNA structures in a process critical for neuronal function. Editing levels at individual editing sites span a broad range and are mediated by both cis-acting elements (surrounding RNA sequence and secondary structure) and trans-acting factors. Here, we aim to determine the roles that cis-acting elements and trans-acting factors play in regulating editing levels. Using two closely related Drosophila species, D. melanogaster and D. sechellia, and their F1 hybrids, we dissect the effects of cis sequences from trans regulators on editing levels by comparing species-specific editing in parents and their hybrids. We report that cis sequence differences are largely responsible for editing level differences between these two Drosophila species. This study presents evidence for cis sequence and structure changes as the dominant evolutionary force that modulates RNA editing levels between these Drosophila species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.