Evidence map›Paper›PMID 25921439›Full record

ArticleThe Journal of pediatrics2015

Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates.

Rebecca M Nachman, Stephen D Fox, W Christopher Golden, Erica Sibinga, John D Groopman, Peter S J Lees

Open access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rebecca M NachmanDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Stephen D FoxCancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD.
W Christopher GoldenEudowood Neonatal Pulmonary Division, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Erica SibingaDivision of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
John D GroopmanDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Peter S J LeesDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Johns Hopkins University · USFrederick National Laboratory for Cancer Research · USJohns Hopkins Medicine · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
PILOT STUDY--ACID FOG, AN EXPERIMENTAL MODELP30ES003819 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GROOPMAN, JOHN D · 1985 to 2012
$22.6M
Validation and Application of Risk, Biomarkers in Human StudiesP01ES006052 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI KENSLER, THOMAS A · 1993 to 2012
$22.6M
Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
NCI NIH HHS N01 CO012400NCI NIH HHS N01-CO-12400NCI NIH HHS P30 CA006973NIEHS NIH HHS P01 ES006052NIEHS NIH HHS P30 ES003819NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

objectiveTo determine the balance of metabolism of free bisphenol A (BPA) to the inactive conjugate, BPA glucuronide (BPAG), in neonates. STUDY

designFree BPA and BPAG concentrations were measured in 78 urine samples collected between December 2012 and August 2013 from a cohort of 44 healthy full term (≥ 37 weeks' gestation) neonates at 2 intervals (3-6 days and 7-27 days of age). A questionnaire was administered at the time of sample collection. Neonates recruited into the study were born in an urban, tertiary care hospital.

resultsOnly BPAG was detected in the urine samples; concentrations ranged from <0.1 μg/L to 11.21 μg/L (median: 0.27 μg/L). Free BPA concentrations were below the limit of quantification of 0.1 μg/L. Age, but not sex or type of diet, was significantly associated with urinary BPAG concentration (P = .002).

conclusionsOur results illustrate widespread BPA exposure in healthy full-term neonates and efficient conjugation of BPA to its readily excretable and biologically inactive form (BPAG) as early as 3 days of age. Factors other than type of diet may be important contributors to BPA exposure in neonates.

Indexed as

Age FactorsBenzhydryl CompoundsBisphenol A CompoundsBreast FeedingFemaleGlucuronidesHumansInfant FormulaInfant, NewbornMalePhenolsSex FactorsBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol A glucuronideGlucuronidesPhenols

Identifiers

PMID25921439
PMCPMC4485942
OpenAlexW2060646008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.