ArticleInternational journal of epidemiology2015
Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers.
Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Advances in epigenetic therapy for esophageal cancer.Clinical epigenetics · 2026Review
- Gene Variants in Components of the microRNA Processing Pathway in Chronic Myeloid Leukemia.Genes · 2024Article
- Mendelian randomization analysis of atopic dermatitis and esophageal cancer in East Asian and European populations.The World Allergy Organization journal · 2024Article
- Review
- Exploring the Association Between PRC2 Genes Variants and Lung Cancer Risk in Chinese Han Population.OncoTargets and therapy · 2023Article
- Rare variants confer shared susceptibility to gastrointestinal tract cancer risk.Frontiers in oncology · 2023Article
- Clinical Relevance of Gastroesophageal Cancer Associated SNPs for Oncologic Outcome After Curative Surgery.Annals of surgical oncology · 2022Article
- Epigenetic modifications in esophageal cancer: An evolving biomarker.Frontiers in genetics · 2022Review
- Epigenetic Regulator KDM4D Restricts TumorigenesisFrontiers in oncology · 2021Article
- The Significance of HOXC11 and LSH in Survival Prediction in Gastric Adenocarcinoma.OncoTargets and therapy · 2021Article
- Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer.Nucleic acids research · 2019Article
- Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.International journal of cancer · 2017Article
- Cancer subtypes in aetiological research.European journal of epidemiology · 2017Article
- From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive.International journal of epidemiology · 2015Article
Corrections and comments
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Authors and funding
25 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundPopulations in north central China are at high risk for oesophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), and genetic variation in epigenetic machinery genes and pathways may contribute to this risk.
methodsWe used the adaptive multilocus joint test to analyse 192 epigenetic genes involved in chromatin remodelling, DNA methylation and microRNA biosynthesis in 1942 ESCC and 1758 GC cases [1126 cardia (GCA) and 632 non-cardia adenocarcinoma (GNCA)] and 2111 controls with Chinese ancestry. We examined potential function of risk alleles using in silico and expression quantitative trait loci (eQTLs) analyses.
resultsSuggestive pathway-based associations were observed for the overall epigenetic (P-value(PATH) = 0.034) and chromatin remodelling (P-value(PATH) = 0.039) pathways with risk of GCA, but not GC, GNCA or ESCC. Overall, 37 different epigenetic machinery genes were associated with risk of one or more upper gastrointestinal (UGI) cancer sites (P-value(GENE )< 0.05), including 14 chromatin remodelling genes whose products are involved in the regulation of HOX genes. We identified a gastric eQTL (rs12724079; rho = 0.37; P = 0.0006) which regulates mRNA expression of ASH1L. Several suggestive eQTLs were also found in oesophageal (rs10898459 in EED), gastric cardia (rs7157322 in DICER1; rs8179271 in ASH1L), and gastric non-cardia (rs1790733 in PPP1CA) tissues.
conclusionsResults of our analyses provide limited but suggestive evidence for a role of epigenetic gene variation in the aetiology of UGI cancer.
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