ArticlePsychopharmacology2015
Role of CB2 receptors in social and aggressive behavior in male mice.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Cannabidiol prevents cognitive and social deficits in a male rat model of Alzheimer's disease through CB1 activation and inflammation modulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder.Journal of biomedical science · 2025Review
- The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses.Psychological medicine · 2023Review
- Review
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- Aggression in Group-Housed Male Mice: A Systematic Review.Animals : an open access journal from MDPI · 2022Review
- CB2 Receptor Involvement in the Treatment of Substance Use Disorders.Biomolecules · 2021Review
- Endocannabinoids and Precision Medicine for Mood Disorders and Suicide.Frontiers in psychiatry · 2021Article
- Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.Cannabis and cannabinoid research · 2019Article
- 5-HTBrain and behavior · 2018Article
- The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders.Frontiers in behavioral neuroscience · 2018Review
- The endocannabinoid system as a target for novel anxiolytic drugs.Neuroscience and biobehavioral reviews · 2017Review
- Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism.Neural plasticity · 2017Article
- Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders.Frontiers in neuroscience · 2016Review
- "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression.Aggression and violent behaviorArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleMale CB1KO mice exhibit stronger aggressive responses than wild-type mice.
objectiveThis study was designed to examine the role of cannabinoid CB2r in social and aggressive behavior.
methodsThe social interaction test and resident-intruder paradigm were performed in mice lacking CB2r (CB2KO) and in wild-type (WT) littermates. The effects of the CB2r selective agonist JWH133 (1 and 2 mg/kg) on aggression were also evaluated in Oncins France 1 (OF1) mice. Gene expression analyses of monoamine oxidase-A (MAO-A), catechol-o-methyltransferase (COMT), 5-hydroxytryptamine transporter (5-HTT), and 5-HT1B receptor (5HT1Br) in the dorsal raphe nuclei (DR) and the amygdala (AMY) were carried out using real-time PCR.
resultsGroup-housed CB2KO mice exhibited higher levels of aggression in the social interaction test and displayed more aggression than resident WT mice. Isolation increased aggressive behavior in WT mice but did not affect CB2KO animals; however, the latter mice exhibited higher levels of social interaction with their WT counterparts. MAO-A and 5-HTT gene expression was significantly higher in grouped CB2KO mice. The expression of 5HT1Br, COMT, and MAO-A in the AMY was more pronounced in CB2KO mice than in WT counterparts. Acute administration of the CB2 agonist JWH133 significantly reduced the level of aggression in aggressive isolated OF1 mice, an effect that decreased after pretreatment with the CB2 receptor antagonist AM630.
conclusionOur results suggest that CB2r is implicated in social interaction and aggressive behavior and deserves further consideration as a potential new target for the management of aggression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.