Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Structural plasticity of remote cortical brain regions is determined by connectivity to the primary lesion in subcortical stroke.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Cortical Thickness of Brain Areas Beyond Stroke Lesions and Sensory-Motor Recovery: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.Nature communications · 2021Trial
- Cortical atrophy and transcallosal diaschisis following isolated subcortical stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Deep grey nuclei automated assessment in acute-subacute phase of middle cerebral artery cortical stroke helps predict the 3-month outcome.Brain imaging and behavior · 2026Article
- The morphometric features derived as the predictors of acute ischemic stroke recurrence.Frontiers in neuroscience · 2026Article
- Post-stroke brain functional reorganization is associated with glymphatic dysfunction during stroke recovery.Brain informatics · 2025Article
- Brain changes in stroke patients during rehabilitation: a longitudinal study.Frontiers in neuroscience · 2025Article
- Assessing the cortical microstructure in contralesional sensorimotor areas after stroke.Brain communications · 2024Article
- Normative connectome-based analysis of sensorimotor deficits in acute subcortical stroke.Frontiers in neuroscience · 2024Article
- Cortical microstructural involvement in cerebral small vessel disease.Cerebral circulation - cognition and behavior · 2024Article
- Brain computed tomography perfusion analysis in HIV-seropositive adults with and without neurocognitive impairment in Nigeria: outcomes and challenges of a pilot study.The Pan African medical journal · 2023Article
- Alterations via inter-regional connective relationships in Alzheimer's disease.Frontiers in human neuroscience · 2023Article
- Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.Frontiers in neuroscience · 2022Article
- Relationship Between Cortical Excitability Changes and Cortical Thickness in Subcortical Chronic Stroke.Frontiers in neurology · 2022Article
- Functional connectome reorganization relates to post-stroke motor recovery and structural and functional disconnection.NeuroImage · 2021Article
- Long-term monitoring of chronic demyelination and remyelination in a rat ischemic stroke model using macromolecular proton fraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Cortical N-acetylaspartate concentrations are impacted in chronic stroke but do not relate to motor impairment: A magnetic resonance spectroscopy study.Human brain mapping · 2021Article
- Cortical degeneration detected by neurite orientation dispersion and density imaging in chronic lacunar infarcts.Quantitative imaging in medicine and surgery · 2021Article
- Automated MRI-based volumetry of basal ganglia and thalamus at the chronic phase of cortical stroke.Neuroradiology · 2020Article
- Patterns of motor recovery and structural neuroplasticity after basal ganglia infarcts.Neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical atrophy as demonstrated by measurement of cortical thickness (CT) is a hallmark of various neurodegenerative diseases. In the wake of an acute ischemic stroke, brain architecture undergoes dynamic changes that can be tracked by structural and functional magnetic resonance imaging studies as soon as 3 months after stroke. In this study, we measured changes of CT in cortical areas connected to subcortical stroke lesions in 12 patients with upper extremity paresis combining white-matter tractography and semi-automatic measurement of CT using the Freesurfer software. Three months after stroke, a significant decrease in CT of -2.6% (median, upper/lower boundary of 95% confidence interval -4.1%/-1.1%) was detected in areas connected to ischemic lesions, whereas CT in unconnected cortical areas remained largely unchanged. A cluster of significant cortical thinning was detected in the superior frontal gyrus of the stroke hemisphere using a surface-based general linear model correcting for multiple comparisons. There was no significant correlation of changes in CT with clinical outcome parameters. Our results show a specific impact of subcortical lesions on distant, yet connected cortical areas explainable by secondary neuro-axonal degeneration of distant areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.