Evidence map›Paper›PMID 25920807›Full record

ArticlePsychiatry research2015

Genetic variants within the serotonin transporter associated with familial risk for major depression.

Ardesheer Talati, Guia Guffanti, Zagaa Odgerel, Iuliana Ionita-Laza, Heli Malm, Andre Sourander, Alan S Brown, Priya J Wickramaratne, Jay A Gingrich, Myrna M Weissman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The adaptive brain in mental health: overcoming inherited risk factors.Journal of psychiatry & neuroscience : JPN · 2017
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ardesheer TalatiDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: talatia@nyspi.columbia.edu.
Guia GuffantiDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: Guffant@nyspi.columbia.edu.
Zagaa OdgerelDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: Odgerel@nyspi.columbia.edu.
Iuliana Ionita-LazaDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA. Electronic address: ii2135@columbia.edu.
Heli MalmDepartment of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: Heli.malm@hus.fi.
Andre SouranderDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: Andsou@utu.fi.
Alan S BrownDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: asb11@columbia.edu.
Priya J WickramaratneDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: wickramp@nyspi.columbia.edu.
Jay A GingrichDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: jag46@columbia.edu.
Myrna M WeissmanDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: mmw3@columbia.edu.
Columbia University Irving Medical Center · USColumbia University · USUniversity of Turku · FI

Funding

Three Generations at High and Low Risk for Depression Followed LongitudinallyR01MH036197 · NIMH · YALE UNIVERSITY · PI POSNER, JONATHAN E, WEISSMAN, MYRNA M · 1985 to 2020
$15.0M
Serotonergic Modulation of Brain Development: Genetic and Pharmacologic InfluencP50MH090966 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BROWN, ALAN S · 2010 to 2014
$9.6M
Novel Statistical methods for DNA Sequencing Data, and applications to Autism.R01MH095797 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IONITA, IULIANA · 2012 to 2022
$3.1M
Prenatal Smoke Exposure and Offspring Substance Use: An Imaging-Genetics ApproachK01DA029598 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI TALATI, ARDESHEER · 2010 to 2014
$906k
Applications of novel statistical methods to CNVs in autism and schizophreniaR21MH106888 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IONITA, IULIANA · 2015 to 2016
$400k
NIDA NIH HHS K01 DA029598NIDA NIH HHS K01DA029598NIMH NIH HHS 1P50MH090966NIMH NIH HHS 2R01MH36197NIMH NIH HHS P50 MH090966NIMH NIH HHS R01 MH036197NIMH NIH HHS R01 MH095797NIMH NIH HHS R21 MH106888
6 · The paper itself

Abstract

The role of the serotonin transporter promoter linked polymorphism (5HTTLPR) in depression, despite much research, remains unclear. Most studies compare persons with and without depression to each other. We show offspring at high (N = 192) as compared to low (N = 101) familial risk for major depressive disorder were almost four times as likely to have two copies of the short allele at 5HTTLPR, suggesting that incorporation of family history could be helpful in identifying genetic differences.

Indexed as

Genetic Predisposition to DiseaseGenotypeHumansMajor Depressive DisorderPedigreePolymorphism, GeneticRiskSerotonin Plasma Membrane Transport ProteinsSeverity of Illness IndexSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanHigh-risk designrs25531Serotonin transporter linked polymorphic region (5HTTLPR)

Identifiers

PMID25920807
PMCPMC4451257
OpenAlexW2117818095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.