ArticleHeredity2015
Genome-wide QTL mapping of saltwater tolerance in sibling species of Anopheles (malaria vector) mosquitoes.
Article in Heredity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Unravelling the genome of the brackish water malaria vector Anopheles aquasalis.Scientific reports · 2023Article
- Molecular characterization and genotype distribution of thioester-containing protein 1 gene in Anopheles gambiae mosquitoes in western Kenya.Malaria journal · 2022Article
- Transcriptomic, proteomic and ultrastructural studies on salinity-tolerant Aedes aegypti in the context of rising sea levels and arboviral disease epidemiology.BMC genomics · 2021Article
- Review
- Evolutionary superscaffolding and chromosome anchoring to improve Anopheles genome assemblies.BMC biology · 2020Article
- The Genetic Architecture of Post-Zygotic Reproductive Isolation BetweenFrontiers in genetics · 2020Article
- A new species in the major malaria vector complex sheds light on reticulated species evolution.Scientific reports · 2019Article
- Massive introgression drives species radiation at the range limit of Anopheles gambiae.Scientific reports · 2017Article
- Genome-Wide Divergence in the West-African Malaria Vector Anopheles melas.G3 (Bethesda, Md.) · 2016Article
- Transcriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress.Molecular ecology · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Although freshwater (FW) is the ancestral habitat for larval mosquitoes, multiple species independently evolved the ability to survive in saltwater (SW). Here, we use quantitative trait locus (QTL) mapping to investigate the genetic architecture of osmoregulation in Anopheles mosquitoes, vectors of human malaria. We analyzed 1134 backcross progeny from a cross between the obligate FW species An. coluzzii, and its closely related euryhaline sibling species An. merus. Tests of 2387 markers with Bayesian interval mapping and machine learning (random forests) yielded six genomic regions associated with SW tolerance. Overlap in QTL regions from both approaches enhances confidence in QTL identification. Evidence exists for synergistic as well as disruptive epistasis among loci. Intriguingly, one QTL region containing ion transporters spans the 2Rop chromosomal inversion that distinguishes these species. Rather than a simple trait controlled by one or a few loci, our data are most consistent with a complex, polygenic mode of inheritance.
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Registered trials
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