Evidence map›Paper›PMID 25920528›Full record

Trial reportPsycho-oncology2016

Correlates of quality of life in overweight or obese breast cancer survivors at enrollment into a weight loss trial.

Bilgé Pakiz, Patricia A Ganz, Rebecca L Sedjo, Shirley W Flatt, Wendy Demark-Wahnefried, Jingxia Liu, Kathleen Y Wolin, Cheryl L Rock

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Recreational physical activity and health-related quality of life among breast cancer survivors: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
  2. Calidad de Vida: a systematic review of quality of life in Latino cancer survivors in the USA.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Trial
  7. Large-scale North American cancer survivorship surveys: 2011-2019 update.Journal of cancer survivorship : research and practice · 2022
    Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Bilgé PakizDepartment of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Patricia A GanzJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Rebecca L SedjoDepartment of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Shirley W FlattDepartment of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Jingxia LiuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Kathleen Y WolinCoeus Health LLC, Chicago, IL, USA.
Cheryl L RockDepartment of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Reducing Breast Cancer Recurrence with Weight Loss: A Vanguard TrialR01CA148791 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROCK, CHERYL L · 2010 to 2013
$4.9M
NCI NIH HHS CA148791NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA148791
6 · The paper itself

Abstract

objectiveThe purpose of this analysis was to examine the correlates of the physical and psychosocial domains of quality of life (QOL) in a cohort of breast cancer survivors participating in a weight loss intervention trial.

methodsCorrelates of QOL and psychosocial functioning were examined in 692 overweight or obese breast cancer survivors at entry into a weight loss trial. QOL was explored with three measures: Short-form 36 (SF-36), Impact of Cancer scale (IOC), and the Breast Cancer Prevention Trial (BCPT) symptom scales. Available data included information on weight and physical activity, as well as demographic and medical characteristics. Multivariate analyses were used to identify associations adjusted for other characteristics.

resultsIn multivariate analysis, younger age was associated with higher negative impact scores (p < 0.0001). Hispanic, African-American, and Asian women had higher positive IOC impact scores compared with White non-Hispanic women (p < 0.01). Increased number of comorbidities was associated with lower physical and mental QOL scores (p < 0.01). Body mass index was not independently associated with QOL measures. Physical activity was directly associated with physical and mental QOL and IOC positive impact, and inversely related to IOC negative impact and Breast Cancer Prevention Trial symptom scales.

conclusionsQuality-of-life measures in breast cancer survivors are differentially associated with demographic and other characteristics. When adjusted for these characteristics, degree of adiposity among overweight or obese women does not appear to be independently associated with QOL. Among overweight or obese breast cancer survivors, higher level of physical activity is associated with higher QOL across various scales and dimensions.

Indexed as

Weight LossAdultAgedBody Mass IndexBody WeightBreast NeoplasmsEthnicityFemaleHumansMiddle AgedObesityQuality of LifeSurvivors

Identifiers

PMID25920528
PMCPMC4626439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.