ArticleMagnetic resonance in medicine2016
The microstructural correlates of T1 in white matter.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- Evaluating the Influence of Injury-Induced Microstructural Variations on the Efficacy of a Diffusion MRI-Derived Axon Diameter Surrogate.Magnetic resonance in medicine · 2026Article
- Modeling of Fiber Orientation-Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model.Magnetic resonance in medicine · 2026Article
- The Impact of Gadolinium on Quantitative Myelin Metrics in Ex Vivo Spinal Cord.NMR in biomedicine · 2026Article
- Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss.Neurobiology of aging · 2026Article
- Fiber orientation-dependent TMagnetic resonance in medicine · 2025Article
- Evaluation of diffusion time-dependent changes in radial diffusivity as a surrogate for axon diameter.Magnetic resonance in medicine · 2025Article
- A Subtracted-Added-Divided Inversion Recovery (dSIR) Approach to Visualise the Effects of Microstructure on T1 Contrast in Human White Matter.NMR in biomedicine · 2025Article
- Genetic Insights into Brain Morphology: a Genome-Wide Association Study of Cortical Thickness and TNeuroinformatics · 2025Article
- An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter.Scientific reports · 2025Article
- T1 mapping using MP2RAGE in degenerative cervical myelopathy: a longitudinal study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- T1 relaxation and axon fibre configuration in human white matter.NMR in biomedicine · 2024Article
- Tractography from T1-weighted MRI: Empirically exploring the clinical viability of streamline propagation without diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Nonaqueous magnetization following adiabatic and selective pulses in brain: T1 and cross-relaxation dynamics.NMR in biomedicine · 2023Article
- White matter microstructure and longitudinal relaxation time anisotropy in human brain at 3 and 7 T.NMR in biomedicine · 2023Article
- Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology.Frontiers in neuroscience · 2023Article
- Quantitative evaluation of the spinal cord compression in patients with cervical spondylotic myelopathy using synthetic MRI.Frontiers in physiology · 2023Article
- Characterisation of the neonatal brain using myelin-sensitive magnetisation transfer imaging.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Decreased basal ganglia and thalamic iron in early psychotic spectrum disorders are associated with increased psychotic and schizotypal symptoms.Molecular psychiatry · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeSeveral studies have shown strong correlations between myelin content and T1 within the brain, and have even suggested that T1 can be used to estimate myelin content. However, other micro-anatomical features such as compartment size are known to affect longitudinal relaxation rates, similar to compartment size effects in porous media.
methodsT1 measurements were compared with measured or otherwise published axon size measurements in white matter tracts of the rat spinal cord, rat brain, and human brain.
resultsIn both ex vivo and in vivo studies, correlations were present between the relaxation rate 1/T1 and axon size across regions of rat spinal cord with nearly equal myelin content.
conclusionWhile myelination is likely the dominant determinant of T1 in white matter, variations in white matter microstructure, independent of myelin volume fraction, may also be reflected in T1 differences between regions or subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.