Evidence map›Paper›PMID 25920454›Full record

ArticleClinical rheumatology2015

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population.

Marija Perica, Mandica Vidović, Lovro Lamot, Lana Tambić Bukovac, Sanja Kapitanović, Magdalena Perić, Jerko Barbić, Miroslav Harjaček

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Association of TLR4 (896A/G and 1196C/T) Gene Polymorphisms with Asthma Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Marija PericaDepartment of Pediatric Rheumatology, Children's Hospital Srebrnjak, Srebrnjak 100, 10000, Zagreb, Croatia. marija_perica@hotmail.com.
Mandica VidovićDepartment of Pediatric Rheumatology, Children's Hospital Srebrnjak, Srebrnjak 100, 10000, Zagreb, Croatia. vidovicmand@yahoo.com.
Lovro LamotDepartment of Pediatric Rheumatology, Children's Hospital Srebrnjak, Srebrnjak 100, 10000, Zagreb, Croatia. lovro.lamot@gmail.com.
Lana Tambić BukovacDepartment of Pediatric Rheumatology, Children's Hospital Srebrnjak, Srebrnjak 100, 10000, Zagreb, Croatia. lanabukovac@gmail.com.
Sanja KapitanovićRuđer Bošković Institute, Zagreb, Croatia. kapitan@irb.hr.
Magdalena PerićInstitute for Public Health, Osijek, Croatia. magdalena0706@gmail.com.
Jerko BarbićClinical Hospital Centre Osijek, Osijek, Croatia. jerko.barbic@mefos.hr.
Miroslav HarjačekDepartment of Pediatric Rheumatology, Children's Hospital Srebrnjak, Srebrnjak 100, 10000, Zagreb, Croatia. miroslav.harjacek@zg.t-com.hr.
Children's Hospital Srebrnjak · HRUniversity of Zagreb · HRAgricultural Institute Osijek · HRRudjer Boskovic Institute · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNP) of toll-like and NOD-like receptors have been associated with altered receptor activity and modified production of proinflammatory cytokines leading to a number of diseases. Our aim was to determine whether SNP of TLR2 (Arg753Gln), TLR4 (Asp299Gly, Thr399Ile), and NLRP3 (Q705K) influence susceptibility to juvenile spondyloarthrtis (jSpA) and juvenile idiopathic arthritis (JIA). After the DNA extraction, 26 patients with jSpA, 11 with oligoarticular, polyarticular, or systemic JIA, and 40 healthy controls were genotyped for Arg753Gln, Asp299Gly, Thr399Ile, and Q705K SNP using real-time PCR-SNP analysis. Statistically significant difference in genotype frequency for Thr399Ile SNP of TLR4 was observed in the jSpA (χ2 = 6.705, p = 0.035) and not in the JIA group (χ2 = 3005, p = 0.223). Regarding Asp299Gly SNP, no significant difference in genotype frequency was found; however, allele frequency was significant in both jSpA and JIA patients. No significant difference in genotype or allele frequency was observed for Arg735Gln and Q705K SNP. The399Ile polymorphism of TLR4 may be responsible for altered immune response to microbial infection in variant carriers and represent a mechanism of triggering overproduction of proinflammatory cytokines and long-term inflammation in jSpA. SNP of TLR2, NLRP3, and TLR4 (Asp299Gly) were not associated with jSpA or JIA.

Indexed as

AdolescentAdultArthritis, JuvenileCarrier ProteinsCase-Control StudiesChildCroatiaFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHeterozygoteHumansMaleMiddle AgedNLR Family, Pyrin Domain-Containing 3 ProteinCarrier ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4Juvenile idiopathic arthritisJuvenile spondyloarthritisSingle nucleotide polymorphismToll-like receptor

Identifiers

PMID25920454
OpenAlexW1808622842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.