Evidence map›Paper›PMID 25920424›Full record

SynthesisEuropean journal of clinical nutrition2015

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis.

M Warthon-Medina, V H Moran, A-L Stammers, S Dillon, P Qualter, M Nissensohn, L Serra-Majem, N M Lowe

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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  20. Autosomal recessiveCold Spring Harbor molecular case studies · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

M Warthon-MedinaInternational Institute of Nutritional Sciences and Applied Food Safety Studies, University of Central Lancashire, Preston, UK.
V H MoranMaternal and Infant Nutrition and Nurture Unit MAINN, University of Central Lancashire, Preston, UK.
A-L StammersInternational Institute of Nutritional Sciences and Applied Food Safety Studies, University of Central Lancashire, Preston, UK.
S DillonInternational Institute of Nutritional Sciences and Applied Food Safety Studies, University of Central Lancashire, Preston, UK.
P QualterSchool of Psychology, University of Central Lancashire, Preston, UK.
M Nissensohn1] Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain [2] Ciber Obn Physiopathology of Obesity and Nutrition, Institute of Health "Carlos III", Madrid, Spain.
L Serra-Majem1] Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain [2] Ciber Obn Physiopathology of Obesity and Nutrition, Institute of Health "Carlos III", Madrid, Spain.
N M LoweInternational Institute of Nutritional Sciences and Applied Food Safety Studies, University of Central Lancashire, Preston, UK.
University of Central Lancashire · GBUniversidad de Las Palmas de Gran Canaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In developing countries, deficiencies of micronutrients are thought to have a major impact on child development; however, a consensus on the specific relationship between dietary zinc intake and cognitive function remains elusive. The aim of this systematic review was to examine the relationship between zinc intake, status and indices of cognitive function in children and adults. A systematic literature search was conducted using EMBASE, MEDLINE and Cochrane Library databases from inception to March 2014. Included studies were those that supplied zinc as supplements or measured dietary zinc intake. A meta-analysis of the extracted data was performed where sufficient data were available. Of all of the potentially relevant papers, 18 studies met the inclusion criteria, 12 of which were randomised controlled trials (RCTs; 11 in children and 1 in adults) and 6 were observational studies (2 in children and 4 in adults). Nine of the 18 studies reported a positive association between zinc intake or status with one or more measure of cognitive function. Meta-analysis of data from the adult's studies was not possible because of limited number of studies. A meta-analysis of data from the six RCTs conducted in children revealed that there was no significant overall effect of zinc intake on any indices of cognitive function: intelligence, standard mean difference of <0.001 (95% confidence interval (CI) -0.12, 0.13) P=0.95; executive function, standard mean difference of 0.08 (95% CI, -0.06, 022) P=0.26; and motor skills standard mean difference of 0.11 (95% CI -0.17, 0.39) P=0.43. Heterogeneity in the study designs was a major limitation, hence only a small number (n=6) of studies could be included in the meta-analyses. Meta-analysis failed to show a significant effect of zinc supplementation on cognitive functioning in children though, taken as a whole, there were some small indicators of improvement on aspects of executive function and motor development following supplementation but high-quality RCTs are necessary to investigate this further.

Indexed as

CognitionDietDietary SupplementsEvidence-Based MedicineNeurogenesisNutritional StatusAged, 80 and overAgingChild DevelopmentChild Nutritional Physiological PhenomenaChild, PreschoolCognition DisordersCognitive DysfunctionDeficiency DiseasesElder Nutritional Physiological PhenomenaExecutive FunctionZinc

Identifiers

PMID25920424
OpenAlexW2165959332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.